Evaluation in children of the standard diuretic renogram with furosemide at 20min, as compared to the diuretic renogram with furosemide after 2min

Abstract

Purpose: The aims of this study in children were a) to compare the renogram with furosemide at 20min (F+20) with the renogram obtained by injecting furosemide after 2min (F+2) and b) to define the normal values of parameters for the technetium-99m mercapto-acetyl-triglycine (99mTc MAG3) diuresis renography. Patients and Methods: The investigation was carried out on the sample of 77 children: 41 boys and 36 girls (median age: 26 months, age range 2-120 months) with unilateral antenatally detected hydronephrosis (HN) and contralateral normal kidney. They were divided into two groups. Group 1 consisted of 33 children who underwent standard F+20 diuresis renography, and Group 2 of 44 children with F+2 renography. Only the normal kidneys were included in the analysis. In total, 77 kidneys were analyzed. The International Atomic Energy Agency (IAEA) software package was applied to process the studies and the following parameters were analyzed: Tmax, diuresis nephrogram in children have been calculated by the means of the IAEA software. Applying these values to semi-quantitative MAG3 parameters may help in differentiation between normal and abnormal finding of diuresis renography in children. The semi-quantitative parameters facilitate the comparison between studies during follow/up and contribute to better management of children with HN. [Projekat Ministarstva nauke Republike Srbije, br. 175018]