Association of rs4646903 and rs1048943 CYP1A1 estrogen metabolizing gene polymorphisms with estrogen receptorpositive breast cancer in Kenyan women

Pub Date : 2023-01-01 DOI:10.2298/abs230115005m
Mary Murithi, S. Nyanjom, V. Mobegi, S. Shahin, Francis Makokha
{"title":"Association of rs4646903 and rs1048943 CYP1A1 estrogen metabolizing gene polymorphisms with estrogen receptorpositive breast cancer in Kenyan women","authors":"Mary Murithi, S. Nyanjom, V. Mobegi, S. Shahin, Francis Makokha","doi":"10.2298/abs230115005m","DOIUrl":null,"url":null,"abstract":"Breast cancer is the most prevalent neoplasm and the second leading cause of death among females in Kenya. Estrogen and its metabolites are known risk factors for breast cancer. Polymorphisms in these genes and breast cancer susceptibility are unique among different populations. This study aimed to determine the probable associations between estrogen-metabolizing gene variations and other risk factors for breast cancer risk in Kenyan women. Buffy coat samples were obtained from patients diagnosed with estrogen receptor-positive breast cancer, benign breast disease, and healthy volunteers. Genotyping of target polymorphisms was conducted using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis. The rs4646903 variant genotype CC was associated with breast cancer in the case-control model (P=0.001); the heterozygous genotype TC (P=0.01) and the luminal B molecular subtype (P=0.02) showed increased odds of late-stage breast cancer. The rs1048943 variant genotype GG was associated with breast cancer in the case-benign model (P=0.04), whereas CG was associated with breast cancer in the case-control model (P=0.02). These findings imply that the rs4646903 and rs1048943 variant genotypes are involved in breast cancer risk in Kenyan women. Hence, they may be explored further as potential markers for the disease.","PeriodicalId":0,"journal":{"name":"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.2298/abs230115005m","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Breast cancer is the most prevalent neoplasm and the second leading cause of death among females in Kenya. Estrogen and its metabolites are known risk factors for breast cancer. Polymorphisms in these genes and breast cancer susceptibility are unique among different populations. This study aimed to determine the probable associations between estrogen-metabolizing gene variations and other risk factors for breast cancer risk in Kenyan women. Buffy coat samples were obtained from patients diagnosed with estrogen receptor-positive breast cancer, benign breast disease, and healthy volunteers. Genotyping of target polymorphisms was conducted using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis. The rs4646903 variant genotype CC was associated with breast cancer in the case-control model (P=0.001); the heterozygous genotype TC (P=0.01) and the luminal B molecular subtype (P=0.02) showed increased odds of late-stage breast cancer. The rs1048943 variant genotype GG was associated with breast cancer in the case-benign model (P=0.04), whereas CG was associated with breast cancer in the case-control model (P=0.02). These findings imply that the rs4646903 and rs1048943 variant genotypes are involved in breast cancer risk in Kenyan women. Hence, they may be explored further as potential markers for the disease.
分享
查看原文
rs4646903和rs1048943 CYP1A1雌激素代谢基因多态性与肯尼亚女性雌激素受体阳性乳腺癌的关系
乳腺癌是最常见的肿瘤,也是肯尼亚女性死亡的第二大原因。雌激素及其代谢物是乳腺癌的已知危险因素。这些基因的多态性和乳腺癌易感性在不同的人群中是独特的。本研究旨在确定肯尼亚妇女雌激素代谢基因变异与乳腺癌风险的其他危险因素之间的可能关联。从雌激素受体阳性乳腺癌患者、良性乳腺疾病患者和健康志愿者中获得了褐色外套样本。采用聚合酶链反应(PCR)-限制性片段长度多态性(RFLP)分析对目标多态性进行基因分型。在病例-对照模型中,rs4646903变异基因型CC与乳腺癌相关(P=0.001);杂合子基因型TC (P=0.01)和luminal B分子亚型(P=0.02)增加了晚期乳腺癌的发生几率。rs1048943变异基因型GG在病例-良性模型中与乳腺癌相关(P=0.04),而CG在病例-对照模型中与乳腺癌相关(P=0.02)。这些发现表明,rs4646903和rs1048943变异基因型与肯尼亚妇女的乳腺癌风险有关。因此,它们可能会被进一步探索作为该疾病的潜在标记物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信