SENSITIVE SPECTROPHOTOMETRIC DETERMINATION OF TRIPROLIDINE HYDROCHLORIDE DRUG IN THE CAPSULES VIA ION PAIR COMPLEX FORMATION

IF 0.5 4区 化学 Q4 CHEMISTRY, MULTIDISCIPLINARY
S. Abdulrahman, Jalal Qazzan
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引用次数: 0

Abstract

The objective of this study was to develop two simple and selective visible spectrophotometric methods for the determination of antihistamine drug triprolidine hydrochloride (TRH) in the capsules. The methods were based on the formation of ion-pair complexes between TRH and two dyes, namely, bromocresol green (BCG) and bromophenol blue (BPB). The produced ion-pair complexes were measured at 415 and 410 nm for BCG and BPB methods, respectively. Beer’s law was applicable in the concentration ranges of 2.50-15.0 µg mL-1 TRH for both methods. The molar absorptivity values were found to be 2.12 × 104 and 2.07 × 104 L mol-1 cm-1 for the BCG method and BPB method, respectively, and the Sandell’s sensitivity values were 0.0149 and 0.0152 µg cm-2. The limits of detection and quantification were calculated and found to be 0.29 and 0.86 µg mL-1 for the BCG method and 0.31 and 0.95 µg mL-1 for the BPB method. The methods were applied successfully for TRH determination in bulk drug and in the capsules.
离子对络合物形成灵敏分光光度法测定盐酸曲普利定胶囊中药物含量
建立两种简便、选择性的可见分光光度法测定胶囊中抗组胺药物盐酸曲普利定(TRH)的含量。该方法是基于TRH与两种染料,即溴甲酚绿(BCG)和溴酚蓝(BPB)之间形成离子对配合物。用BCG法和BPB法分别在415 nm和410 nm处测得离子对配合物。两种方法的浓度范围为2.50 ~ 15.0µg mL-1 TRH,均适用Beer定律。BCG法和BPB法的摩尔吸光度分别为2.12 × 104和2.07 × 104 L mol-1 cm-1, Sandell的灵敏度分别为0.0149和0.0152µg cm-2。计算出BCG法的检出限和定量限分别为0.29和0.86µg mL-1, BPB法的检出限分别为0.31和0.95µg mL-1。该方法可用于原料药和胶囊中TRH的测定。
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来源期刊
Quimica Nova
Quimica Nova 化学-化学综合
CiteScore
1.60
自引率
12.50%
发文量
72
审稿时长
2-4 weeks
期刊介绍: Química Nova publishes in portuguese, spanish and english, original research articles, revisions, technical notes and articles about education in chemistry. All the manuscripts submitted to QN are evaluated by, at least, two reviewers (from Brazil and abroad) of recognized expertise in the field of chemistry involved in the manuscript. The Editorial Council can be eventually asked to review manuscripts. Editors are responsible for the final edition of QN.
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