Development of a 1GHz NMR Magnet

T. Kiyoshi
{"title":"Development of a 1GHz NMR Magnet","authors":"T. Kiyoshi","doi":"10.2221/JCSJ.37.10","DOIUrl":null,"url":null,"abstract":"NMR spectrometers are considered to be an indispensable tool for structural biology. They are applied to determine the stereoscopic structure of protein molecules and to identify the chemical-reacting part between proteins and candidate medicines. Because the sensitivity and resolution of NMR spectrometers are improved with external magnetic fields, development projects of high-field NMR spectrometers have been carried out worldwide. At the Tsukuba Magnet Laboratory of the National Institute for Materials Science, the development of a high-field NMR magnet has been under way since 1995. The final target is to generate an additional 2.4T with an innermost coil, resulting in a central field of 23.5T corresponding to a 1H NMR frequency of 1GHz in a 54mm diameter room-temperature bore. The magnet was confirmed to operate as a high-resolution NMR magnet at 920MHz, using a Nb3Sn innermost coil. In the case of an NMR magnet, the required conditions of field homogeneity and stability are very strict. In this paper, we introduce the design issues of an NMR magnet by using our developed NMR magnet as an example. The future vision for high-field superconducting NMR magnets generating a field of 23.5T or more is also described.","PeriodicalId":93144,"journal":{"name":"Teion kogaku = Cryogenic engineering : [official journal of the Cryogenic Association of Japan]","volume":"37 1","pages":"10-17"},"PeriodicalIF":0.0000,"publicationDate":"2002-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Teion kogaku = Cryogenic engineering : [official journal of the Cryogenic Association of Japan]","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2221/JCSJ.37.10","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

NMR spectrometers are considered to be an indispensable tool for structural biology. They are applied to determine the stereoscopic structure of protein molecules and to identify the chemical-reacting part between proteins and candidate medicines. Because the sensitivity and resolution of NMR spectrometers are improved with external magnetic fields, development projects of high-field NMR spectrometers have been carried out worldwide. At the Tsukuba Magnet Laboratory of the National Institute for Materials Science, the development of a high-field NMR magnet has been under way since 1995. The final target is to generate an additional 2.4T with an innermost coil, resulting in a central field of 23.5T corresponding to a 1H NMR frequency of 1GHz in a 54mm diameter room-temperature bore. The magnet was confirmed to operate as a high-resolution NMR magnet at 920MHz, using a Nb3Sn innermost coil. In the case of an NMR magnet, the required conditions of field homogeneity and stability are very strict. In this paper, we introduce the design issues of an NMR magnet by using our developed NMR magnet as an example. The future vision for high-field superconducting NMR magnets generating a field of 23.5T or more is also described.
1GHz核磁共振磁体的研制
核磁共振波谱仪被认为是结构生物学研究中不可缺少的工具。它们被应用于确定蛋白质分子的立体结构和确定蛋白质与候选药物之间的化学反应部分。由于外磁场的作用提高了核磁共振仪的灵敏度和分辨率,高场核磁共振仪的研制项目已在世界范围内展开。在日本国家材料科学研究所的筑波磁体实验室,自1995年以来一直在开发一种高场核磁共振磁体。最终目标是通过最内层线圈产生额外的2.4T,从而在直径为54mm的室温孔中产生23.5T的中心场,对应于1GHz的1H NMR频率。该磁体被确认为920MHz高分辨率核磁共振磁体,使用最内层的Nb3Sn线圈。在核磁共振磁体中,对磁场均匀性和稳定性的要求是非常严格的。本文以研制的核磁共振磁体为例,介绍了核磁共振磁体的设计问题。对产生23.5T或更高磁场的高场超导核磁共振磁体的未来愿景也进行了描述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信