Segmentation of Overlapping Chromosome Images Using Computational Geometry

Q3 Multidisciplinary
Wacharapong Srisang, K. Jaroensutasinee, M. Jaroensutasinee
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引用次数: 26

Abstract

Current systems for automatic chromosome classification are interactive and require human intervention for correct separation between touching and overlapping chromosomes. Special separation methods are required to segregate chromosomes because they are non-rigid objects. This study develops a new technique to separate overlapping chromosomes based on computational geometry. This technique requires the identification of all possible cut points from the contour line of overlapping chromosomes, using Voronoi diagrams and Delaunay triangulations to select the four target cut points and cut overlapping chromosomes into two chromosomes. We test our algorithm on 35 overlapping chromosome images and find that 28 out of 35 overlapping chromosomes images can be separated correctly (i.e. 80.0 %). Three out of the 35 images are separate incorrectly (i.e. 8.6 %) and four out of 35 images are not separable by our algorithm (i.e. 11.4 %).
基于计算几何的重叠染色体图像分割
目前的自动染色体分类系统是交互式的,需要人为干预才能正确分离接触和重叠的染色体。由于染色体是非刚性物体,因此需要特殊的分离方法来分离染色体。本研究提出了一种基于计算几何的重叠染色体分离新技术。该技术需要从重叠染色体的等高线上识别出所有可能的切割点,利用Voronoi图和Delaunay三角剖分法选择四个目标切割点,将重叠染色体切割成两条染色体。我们对35张重叠的染色体图像进行了测试,发现35张重叠的染色体图像中有28张可以正确分离(即80.0%)。35张图像中有3张分离不正确(即8.6%),35张图像中有4张无法通过我们的算法分离(即11.4%)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Walailak Journal of Science and Technology
Walailak Journal of Science and Technology Multidisciplinary-Multidisciplinary
CiteScore
0.80
自引率
0.00%
发文量
0
审稿时长
24 weeks
期刊介绍: The Walailak Journal of Science and Technology (Walailak J. Sci. & Tech. or WJST), is a peer-reviewed journal covering all areas of science and technology, launched in 2004. It is published 12 Issues (Monthly) by the Institute of Research and Innovation of Walailak University. The scope of the journal includes the following areas of research : - Natural Sciences: Biochemistry, Chemical Engineering, Chemistry, Materials Science, Mathematics, Molecular Biology, Physics and Astronomy. -Life Sciences: Allied Health Sciences, Biomedical Sciences, Dentistry, Genetics, Immunology and Microbiology, Medicine, Neuroscience, Nursing, Pharmaceutics, Psychology, Public Health, Tropical Medicine, Veterinary. -Applied Sciences: Agricultural, Aquaculture, Biotechnology, Computer Science, Cybernetics, Earth and Planetary, Energy, Engineering, Environmental, Food Science, Information Technology, Meat Science, Nanotechnology, Plant Sciences, Systemics
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