Induction of apoptosis by the aqueous and ethanolic leaf extract of Vitex negundo L. in MCF-7 human breast cancer cells.

Abstract

The aim of this investigation was to evaluate the anti-proliferative potential of aqueous and ethanolic extract from Vitex negundo against human breast cancer cell (MCF-7). The aqueous and ethanol extract from V. negundo potently inhibited growth of MCF-7 in a concentration-dependent manner. V. negundo pretreatment resulted in deferential cell viability and IC50 value were observed in MCF-7 cell line but not in control cell line. The above result suggested that V. negundo has a potential benefits in breast cancer cells. Keywords - Anti-cancer, anti-proliferative, breast cancer, cytotoxicity, V. negundo , MCF-7