Monte Carlo-based optimization of a gamma probe system for sentinel lymph node mapping

IF 0.1 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Iranian Journal of Nuclear Medicine Pub Date : 2019-01-01 DOI:10.18502/IRJNM.V27I1.968

Azadeh Nikoogoftar, M. Shamsaie, N. Zeraatkar, M. Ay

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引用次数: 0

Abstract

Introduction: Sentinel lymph node biopsy (SLNB) is a standard surgical technique to identify sentinel lymph node (SLN) for the staging of early breast cancer. Nowadays, two methods are used for the identification of SLN: blue dye method aiding visually and radioactive dye using gamma detector. A wide range of gamma probe systems with different design and performance are used in intra-operative surgery. The performance of the probes is evaluated by some parameters such as sensitivity, spatial resolution, angular resolution, and shielding efficiency. Methods: In this study, we simulated a gamma probe system, SURGEOGUIDE II based on CsI(Tl) scintillator, a silicon photomultiplier (SiPM), and a tungsten collimator, using the MCNP4C Monte Carlo (MC) method and comparing with experimental measurement. Finally we modeled a series of probe with various crystal material, crystal length, and collimator hole length to evaluate the sensitivity and the spatial resolution in order to propose the optimal configuration. Results: The sensitivity of the system was measured as 2040 cps/MBq in 30 mm distance from the source. The spatial resolution and angular resolution were 43 mm and 70

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基于蒙特卡罗优化的伽玛探针系统前哨淋巴结映射

前哨淋巴结活检(SLNB)是一项标准的手术技术，以确定前哨淋巴结(SLN)的分期早期乳腺癌。目前用于SLN鉴定的方法主要有两种:肉眼辅助的蓝色染料法和伽玛探测器辅助的放射性染料法。各种不同设计和性能的伽马探针系统被用于术中手术。通过灵敏度、空间分辨率、角分辨率和屏蔽效率等参数对探头的性能进行了评价。方法:采用MCNP4C蒙特卡罗(MC)方法，模拟了基于CsI(Tl)闪烁体、硅光电倍增管(SiPM)和钨准直器的伽马探针系统SURGEOGUIDE II，并与实验测量结果进行了比较。最后对不同晶体材料、不同晶体长度、不同准直孔长度的探针进行了建模，对灵敏度和空间分辨率进行了评估，提出了最优配置。结果:该系统在距离源30mm处的灵敏度为2040 cps/MBq。空间分辨率为43 mm，角分辨率为70 mm

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来源期刊

Iranian Journal of Nuclear Medicine RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

0.30

自引率

33.30%

发文量

期刊介绍： Iranian Journal of Nuclear Medicine is a peer-reviewed biannually journal of the Research Institute for Nuclear Medicine, Tehran University of Medical Sciences, covering basic and clinical nuclear medicine sciences and relevant applications such as molecular imaging, functional and metabolic investigation of disease, radiobiology, dosimetry, radiopharmacy, radiochemistry, instrumentation and computer sciences, etc. The journal particularly welcomes original articles reflecting the local or worldwide growing materials as well as common critical problems and interests in the field of nuclear medicine. Also review articles, case reports and letters to the editor in this subject will be accepted.