Wharton's Jelly Stem Cells as Agents for Cancer Therapy

M. Tamura, A. Kawabata, N. Ohta, L. Uppalapati, K. Becker, D. Troyer
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引用次数: 34

Abstract

Stem cell based therapy has significant potential to treat various diseases including primary and metastatic cancers. The umbilical cord matrix stem cells (UCMSC) derived from human umbilical cord Wharton's jelly (also termed WJMSC) have been shown to exhibit low immunogenicity, which potentially negates immune consequences after cytotherapy. The homing ability of human and rat UCMSC to inflammatory tissues, including cancer tissues, further confers upon these cells the potential for targeted cancer therapy. Our previous studies demonstrated that un-engineered human and rat UCMSC significantly attenuated the growth of multiple cancer cell lines in vivo and in vitro through multiple mechanisms. We have also demonstrated that these cells can be engineered to express cytotoxic cytokines before being delivered to the tumor and can be preloaded with nanoparticle payloads and attenuate tumors after homing to them. In this review, intrinsic stem cell-dependent regulation of cancer growth, potential mechanisms involved in this unique biological function, delivery of exogenous anti-cancer agents, and the potential for clinical applications will be discussed.
沃顿的果冻干细胞作为癌症治疗的药剂
干细胞疗法在治疗包括原发性和转移性癌症在内的各种疾病方面具有巨大的潜力。脐带基质干细胞(UCMSC)来源于人脐带沃顿氏冻(也称为WJMSC),已被证明具有低免疫原性,这可能会在细胞治疗后产生免疫后果。人和大鼠UCMSC对炎症组织(包括癌症组织)的归巢能力,进一步赋予了这些细胞靶向癌症治疗的潜力。我们之前的研究表明,未经工程化的人和大鼠UCMSC通过多种机制在体内和体外显著减弱多种癌细胞系的生长。我们还证明,这些细胞在被运送到肿瘤之前可以被改造成表达细胞毒性细胞因子,并且可以预先装载纳米粒子有效载荷,并在返回肿瘤后减弱肿瘤。在这篇综述中,将讨论干细胞对肿瘤生长的内在依赖调节,这种独特生物学功能的潜在机制,外源性抗癌药物的传递以及临床应用的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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