Evaluation of Alpha One Anti-Trypsin andHaptoglobin in Hypertensive Patients in Elele

Abstract

Inflammation is associated with different cardiovascular diseases like in hypertension. This study to evaluate the level of alpha one anti-trypsin (AAT) and haptoglobin in hypertension was carried out on patients attending Madonna University Hospital (MUTH), Elele, Rivers State, Nigeria. The research was done on a total of one hundred (100) subjects. Fifty (50) of this population were hypertensive patients (Test) while fifty (50) were the control. Their age ranged from 45-65 years. Alpha one anti-trypsin and haptoglobin were measured by Mispa Auto-analyzer Nephelometric immunoassay method. The results were analyzed using statistical package for social science (SPSS) version 20. The results showed a significant increase (P<0.05) in haptoglobin in hypertensive subjects (120.9 ± 54.90 mg/dl) when compared with the control (47.7 ± 32.61 mg/dl). Haptoglobin was elevated in hypertension. Hence, level of haptoglobin could be used to predict cardiovascular risk in patients with certain disease conditions. The results also showed significant increase (P<0.05) in the AAT level of hypertensive subjects (293.7 ± 59.86 mg/dl) compared to the control (158.8 ± 52.14 mg/dl) respectively. Alpha one anti-trypsin plays a role as a biomarker in hypertension.