Are Females More Sensitive to MDMA-Related Discriminative Stimuli?

Abstract

are examples of interoceptive cues which enable experienced users to distinguish the effects of MDMA from those of other drugs. Serotonin neurotransmission positively modulates the release of oxytocin into plasma [2]. To test the hypothesis that oxytocin receptor activation contributes to the interoceptive cues of MDMA in male and female rats, two peptidic oxytocin receptor ligands, the agonist carbetocin [3] and antagonist atosiban [4], were utilised in a 3-way drug discrimination paradigm [5].