A Possible Interaction of Voriconazole and Warfarin in a Renal Transplant Recipient

Abstract

A potential warfarin - voriconazole interaction has been identified in one study involving healthy individuals. We report a case where addition of voriconazole possibly increased the international normalized ratio (INR) in a renal transplant patient taking warfarin. The INR elevation was resistant to reversal agents, and the situation may have ulti- mately contributed to a thrombotic episode.