Probiotics in Curing Allergic and Inflammatory Conditions - Research Progress and Futuristic Vision.

IF 4.2 Q3 Pharmacology, Toxicology and Pharmaceutics
K. Dhama, S. K. Latheef, A. Munjal, R. Khandia, H. A. Samad, Hafiz M.N. Iqbal, S. Joshi
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引用次数: 29

Abstract

BACKGROUND Probiotics constitute the viable and beneficial microbes, which offer a dietary means to sustain the balance of gastro-intestinal (GI) microflora. Owing to their multiple health benefits, these have recently gained wide attention among researchers for exploring their potential in safeguarding the health of humans and animals. Probiotics could also modulate host-immune responses, thereby help in counteracting the immunological dysfunctions. Probiotics can inhibit the systemic invasion of pathogens entering through the GI mucosa/ oral cavity and have been found to possess effective prophylactic and therapeutic utilities against various infectious pathogens as well as non-infectious diseases and disorders. OBJECTIVE The present review expedites the role of probiotics in curing the ailments related to allergic and inflammatory disease conditions. METHOD A thorough reviewing of the literature and patents available on probiotics and their role in countering inflammation and allergy was conducted using authentic published resources available on Medline, PubMed, PubMed Central, Science Direct and other scientific databases. The information retrieved has been compiled and analysed pertaining to the theme of the study. RESULTS Various micro-organisms have been evaluated for their probiotic efficacy, among these, the lactic acid bacteria viz. Lactobacillus sp. and Bifidobacterium sp. have extensively been studied and widely exploited. In the current post-globalized era of self and complementary medicines, the concept of probiotics and their therapeutic as well as prophylactic usage is gaining wide acceptance. As more and more bacterial strains are being proven for their pronounced influence on down regulation of immune regulation, atopic, inflammatory conditions, the use of probiotics is getting increased especially in the developed countries where such indications are high in prevalence. Apart from usage in immune related disorders, probiotics have been found to be effective in treating pouchitis, infantile diarrhoea due to infections, bacterial vaginosis, urinary tract infections, dental carries, diabetes, cancers as well augmenting the gut mucosal tolerance to various antibiotics and lactose intolerance. CONCLUSION The resent review gives an insight towards potent utility of this branch of beneficial microbial therapy in allergy and inflammations, which is still in the emerging phase and more scientific evidences need to be explored regarding exploration of the mechanisms of action, further experimental trials and validation of controlled clinical studies in humans along with designing novel strategies for monitoring the possible microbial changes in their composition and metabolism associated with their interaction upon host immune system.
益生菌在治疗过敏和炎症条件-研究进展和未来展望。
背景益生菌是一种有活力和有益的微生物,它为维持胃肠道菌群的平衡提供了一种饮食手段。由于它们具有多种健康益处,最近受到研究人员的广泛关注,他们正在探索它们在保护人类和动物健康方面的潜力。益生菌还可以调节宿主免疫反应,从而有助于对抗免疫功能障碍。益生菌可以抑制病原体进入胃肠道粘膜/口腔的系统性入侵,并被发现对各种感染性病原体以及非感染性疾病和失调具有有效的预防和治疗作用。目的探讨益生菌在治疗过敏性和炎症性疾病中的作用。方法利用Medline、PubMed、PubMed Central、Science Direct和其他科学数据库上的真实出版资源,对益生菌及其在抗炎症和过敏中的作用进行全面的文献和专利审查。检索到的资料已根据该研究的主题进行了汇编和分析。结果多种微生物的益生菌功效已得到评价,其中乳酸菌即乳杆菌和双歧杆菌得到了广泛的研究和开发。在当前自我和补充药物的后全球化时代,益生菌的概念及其治疗和预防使用正在获得广泛接受。随着越来越多的细菌菌株被证明对免疫调节的下调、特应性、炎症性疾病有显著的影响,益生菌的使用越来越多,特别是在发达国家,这些适应症普遍存在。除了用于免疫相关疾病外,益生菌已被发现可有效治疗包囊炎、感染引起的婴儿腹泻、细菌性阴道病、尿路感染、龋齿、糖尿病、癌症,以及增强肠道黏膜对各种抗生素和乳糖不耐症的耐受性。结论本综述揭示了这一有益微生物治疗过敏和炎症的有效应用,但其作用机制仍处于新兴阶段,需要更多的科学证据来探索。进一步的实验试验和人类对照临床研究的验证,以及设计新的策略来监测它们在与宿主免疫系统相互作用相关的组成和代谢方面可能发生的微生物变化。
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来源期刊
CiteScore
3.90
自引率
0.00%
发文量
0
期刊介绍: Recent Patents on Inflammation & Allergy Drug Discovery publishes review articles by experts on recent patents in the field of inflammation and allergy drug discovery e.g. on novel bioactive compounds, analogs and targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in inflammation and allergy drug design and discovery.
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