Recent Patents of Complementary and Alternative Medicine for Allergic Rhinitis.

IF 4.2 Q3 Pharmacology, Toxicology and Pharmaceutics
K. Hon, C. Fung, A. Leung, H. Lam, S. L. Lee
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引用次数: 15

Abstract

Allergic rhinitis (AR) is a common respiratory disease affecting both adults and children worldwide. Affected patients may experience nasal congestion/stuffiness, rhinorrhea (anterior and/or posterior), nasal/ nasopharyngeal itching and sneezing. Allergen avoidance is the principal step in the management. Nasal saline irrigation to remove allergen (s) in the nose is a useful adjunctive therapy in the management of moderate to severe AR. Symptomatic relief and improved quality of life may be achieved in the majority of patients with appropriate pharmacotherapy. Mild-to-moderate cases are usually managed with either an oral second generation antihistamine or an intranasal corticosteroid. More severe cases may require treatment with an intranasal corticosteroid in combination with various oral medications. Patients who require medications for more than 6 months per year or have intolerable side effects from pharmacotherapy can be considered for immunotherapy. A wide range of complementary and alternative medicines (CAM) have also been proposed. This overview evaluates the evidence of use of CAM for AR. Some methods including acupuncture and herbal medicine have supportive evidence, but the efficacy of other CAM is controversial. Conversely, possible side effects of different modalities are often inadequately documented. The herbal formulae include Butterbur, Nigella sativa, Shi-Bi-Lin, Polyherbal formula, Grapeseed extract, Rosmarinic acid, Spirulina, Biminne, and Bhu-zhong-yi-qi-tong. Further research is needed to assess the efficacy and safety before they are employed in treating AR. This review article also discusses recent CAM patents for use in AR, which are exclusively traditional Chinese medicine (TCM) concoctions primarily for oral consumption but two as topical spray. Only 8 pertinent patents, all TCM compositions for treating AR and registered in 2014, were obtained. Description about their efficacy is impressive but objective outcome evaluation tools are lacking.
变应性鼻炎补充和替代药物最新专利。
过敏性鼻炎(AR)是一种常见的呼吸系统疾病,影响全球成人和儿童。受影响的患者可能出现鼻塞/鼻塞、鼻漏(前鼻和/或后鼻)、鼻/鼻咽瘙痒和打喷嚏。避免过敏原是管理的主要步骤。鼻盐水冲洗去除鼻内过敏原是治疗中重度AR的有效辅助疗法。大多数患者通过适当的药物治疗可缓解症状并改善生活质量。轻至中度病例通常采用口服第二代抗组胺药或鼻内皮质类固醇治疗。更严重的病例可能需要鼻内皮质类固醇与各种口服药物联合治疗。每年需要药物治疗超过6个月或药物治疗有无法忍受的副作用的患者可以考虑进行免疫治疗。广泛的补充和替代药物(CAM)也被提出。本综述评估了使用CAM治疗AR的证据。包括针灸和草药在内的一些方法有支持性证据,但其他CAM的疗效存在争议。相反,不同治疗方式可能产生的副作用往往文献记载不足。草药配方包括Butterbur, Nigella sativa,石碧林,多草药配方,葡萄籽提取物,迷迭香酸,螺旋藻,Biminne和补中益气通。在将其用于治疗AR之前,还需要进一步的研究来评估其有效性和安全性。这篇综述文章还讨论了最近用于AR的CAM专利,这些专利主要是用于口服的传统中药(TCM)混合物,但有两种用于局部喷雾。仅获得相关专利8项,均为2014年注册的治疗AR的中药组合物。对其疗效的描述令人印象深刻,但缺乏客观的结果评估工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.90
自引率
0.00%
发文量
0
期刊介绍: Recent Patents on Inflammation & Allergy Drug Discovery publishes review articles by experts on recent patents in the field of inflammation and allergy drug discovery e.g. on novel bioactive compounds, analogs and targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in inflammation and allergy drug design and discovery.
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