Synthetic and Natural Nutritional Supplements: Health "Allies" or Risks to Public Health?

IF 4.2 Q3 Pharmacology, Toxicology and Pharmaceutics
N. Kioukia-Fougia, N. Georgiadis, K. Tsarouhas, F. Vasilaki, Persefoni Fragiadaki, E. Meimeti, C. Tsitsimpikou
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引用次数: 12

Abstract

BACKGROUND The modern way of life involves high stress levels, poor eating habits, lack of exercise, obesity and other detrimental health factors. Nutritional supplements (NS) are complexes of nutrients with variant activity that may infer reversal to nutrient depletion. They tend to be popular amongst social categories associated with the healthy life style, such as the elite and amateur athletes, military people and the general population. OBJECTIVE An overview of the state of play with regard to nutritional supplements - natural and synthetic-, is important both from toxicological and commercial point of view. METHOD From a thorough literature review on nutritional supplements, several patents of application have been identified and herewith reviewed which recommend natural vegetable extracts as food supplements for prophylaxis, therapy, protection of immune system, diabetes, oxidative stress, cancer, chronic inflammations and other health conditions. Besides, nutritional supplements of pharmacological validity and high popularity are discussed relative to their contents and group of use. RESULTS Cases of adulteration or unintentional contamination of commercial products with abusing substances (doping substances, narcotics etc.) or toxic compounds (heavy metals, plant toxics) have shed light to the problem of causing recalls of some products by the FDA. CONCLUSION From the safety/ quality point of view, NS lack of harmonisation and sovereign laws/ institutional controls on the market and their wide commercialization may possibly lead to risks to public health.
合成和天然营养补充剂:健康“盟友”还是公共健康风险?
现代生活方式包括高压力水平、不良饮食习惯、缺乏锻炼、肥胖和其他有害健康因素。营养补充剂(NS)是具有不同活性的营养素的复合物,可以推断营养素消耗的逆转。它们往往在与健康生活方式有关的社会类别中受欢迎,例如精英和业余运动员、军人和一般人群。目的从毒理学和商业的角度对营养补充剂(天然和合成)的现状进行概述是很重要的。方法通过对营养补充剂的全面文献回顾,确定并审查了一些专利申请,这些专利推荐天然植物提取物作为食品补充剂,用于预防,治疗,保护免疫系统,糖尿病,氧化应激,癌症,慢性炎症和其他健康状况。此外,还从营养补充剂的内容和使用人群方面讨论了其药理有效性和高知名度。结果滥用物质(兴奋剂、麻醉品等)或有毒化合物(重金属、植物毒性物质)掺假或无意污染商业产品的案例揭示了导致FDA召回某些产品的问题。结论从安全/质量的角度来看,NS缺乏统一和对市场的主权法律/制度控制及其广泛商业化可能导致公共卫生风险。
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来源期刊
CiteScore
3.90
自引率
0.00%
发文量
0
期刊介绍: Recent Patents on Inflammation & Allergy Drug Discovery publishes review articles by experts on recent patents in the field of inflammation and allergy drug discovery e.g. on novel bioactive compounds, analogs and targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in inflammation and allergy drug design and discovery.
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