ACTION OF TWO NEW NICOTINIC ACID DERIVATIVES ON THE LEVEL OF HIPPOCAMPUS IN RATS

Abstract

Experiments on hippocampal slices in rats showed that new nicotinic acid derivatives LKhT 6-20 and LKhT 7-20 at 5 mM inhibited the СА1 orthodromic population responses by 43  4 and 69  5%, respectively, whereas preparation of comparison mexicor in equal concentration inhibited the responses by 52  4 %. Action of LKhT 7-20 exceeded LKhT6–20 in 1.6 times and mexicor, in 1.3 times. The refore, LKhT 6-20 and LKhT 7-20 inhibit synaptic transmission between Schaffer collaterals and pyramidal СА1 neurons. It can be inferred that hippocampus has a significant role in the central action of these new substances.