TOXICOLOGY ISSUES OF LUNAR DUST EFFECTS ON BIOLOGICAL OBJECTS (LITERATURE REVIEW)

Q4 Biochemistry, Genetics and Molecular Biology

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI:10.21687/0233-528x-2022-56-5-29-37

M.Yu. Barantseva, L. N. Mukhamedieva, D. Ozerov, A. A. Pakhomova, P. V. Lashukov, I. A. Grabeklis

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Abstract

Long-term lunar missions will require a toxicological and hygienic assessment of the biological impact of lunar dust on humans, as one of the main factors limiting the duration of human stay on the lunar surface. This review summarizes the results of scientific research aimed at studying the acute and chronic effects of lunar dust and its imitators when inhaled and intratracheally administered to animals. The analysis of the biological activity of the particles after their penetration into the respiratory tract and lung tissue was carried out. Based on the modern understanding of the pathogenesis of pulmonary fibrosis, a hypothesis was formulated for the development of toxic damage to the lungs when exposed to lunar dust: mechanical damage to the alveolar epithelium by dust particles, increased microvascular permeability, local and systemic autoimmune inflammatory reactions, activation of cytokine regulation of the inflammatory and fibroplastic process in the lungs and heart.

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月球尘埃对生物物体影响的毒理学问题(文献综述)

长期月球任务将需要对月球尘埃对人类的生物影响进行毒理学和卫生评估，这是限制人类在月球表面停留时间的主要因素之一。本文综述了有关月尘及其仿制品吸入和经气管给药对动物急性和慢性影响的科学研究结果。对颗粒进入呼吸道和肺组织后的生物活性进行了分析。基于对肺纤维化发病机制的现代理解，对暴露于月尘时肺毒性损伤的发展提出了一个假设:尘颗粒对肺泡上皮的机械损伤，微血管通透性增加，局部和全身自身免疫炎症反应，激活细胞因子调节肺和心脏的炎症和纤维化过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

0.60

自引率

0.00%

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