TOLERANCE OF MEDICAMENT B-190 (INDRALIN); ITS EFFECT ON PILOT'S PROFESSIONAL ACTIVITIES AND RESISTANCE TO EXTREME FLIGHT FACTORS

Abstract

We undertook analysis of testing tolerance to fast-acting radioprotector B-190 (indralin) by 147 pilots and test-subjects in a number of simulators. Indralin, a direct 1(В)-adrenergic vasopressor, increases peripheral resistance and controls local blood flow. As a result, diastolic and systolic pressure grows and heart rate decreases reflectively for a period of up to an hour. Indralin did not impact endurance of head-to-pelvis g-loading (+5 g, 30 s), hypobaric hypoxia (5 000 m, 30 min), vestibular stimulation (continuous cumulative Coriolis effect), hyperthermia (+35 °С and 55 % relative humidity) and 1-hour physical work at 50 watts in a protective marine outfit and sealed respirator mask. Indralin did not affect physical endurance or performance assessed by functioning of the neuromotor apparatus (dynamic work, static stability, resting and motion tremor, sensorimotor reaction). Investigations of the indralin effects on operator's psychophysiology and efficiency in a flight simulator showed that it did not act dramatically on job quality and attention, visual or motor functions and that operator's self-appraisal remained adequate.