Histopathological study of experimental tooth movement in a rat model of type II diabetes mellitus

Abstract

It is generally thought that orthodontic treatment should be avoided in patients with diabetes mellitus. However, the number of diabetes patients in Japan is increasing and there are circumstances when orthodontic treatment needs to be done. According to the 2012 National Health and Nutrition Survey, about 9.5 million people in Japan had a National Glycohemoglobin Standardization Program (NGSP) HbA1c level of 6.5%, an indicator of diabetes, and 11.0million people had levels of 6.0% to less than 6.5%, indicating prediabetes. Thus, a total of 20.5 million people, or about 16% of the Japanese population, have diabetes or pre -diabetes. Juvenile diabetes has also been increasing in recent years, with a corresponding increase in the number of these children needing orthodontic treatment. However, the phenomena that will occur when orthodontic treatment is actually performed on people with diabetes are not understood at all. Therefore, elucidation of what may occur histopathologically should be of benefit in responding to the needs of these patients. Goto-Kakizaki (GK) rats are an animal model of diabetes that was developed fromWistar rats. 7 GK rats are non-obese rats in which a hyperglycemic condiHistopathological study of experimental tooth movement in a rat model of type II diabetes mellitus