GGT Level as a New Biomarker of COVID-19 Infection; a Systematic Review and Meta‑Analysis Comparing Intensive Care Unit (ICU) Patients with Non-ICU Cases

Q4 Medicine

Infektsionnye Bolezni Pub Date : 2023-01-01 DOI:10.20953/1729-9225-2023-2-47-56

M. Tahani, Shiva Rakhshani Nasab, I. Shahramian, M. Afshari, H. Mirzaei, F. Parooie, M. Salarzaei

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引用次数: 0

Abstract

Gamma-glutamyl transferase (GGT) is an enzyme found in many body organs, and its highest concentration is found in the liver. The level of GGT is increased following liver damage in different diseases. This systematic review and meta-analysis was performed to evaluate GGT levels in COVID-19 patients and determine its predictive role in diagnosing the severity of the disease. The methods used in this systematic review were performed by the PRISMA checklist instructions. Two independent researchers searched international databases (PubMed, Web of Science, Scopus, and Google Scholar) to find related studies published in English from the time of the COVID-19 pandemic to October 2021. Stata software version 11 (StataCorp, College Station, TX, USA) was used for statistical analysis. Serum GGT level in ICU patients was 18.19 units higher than in other patients. This difference was statistically significant. Also, ALT and AST levels among ICU patients were higher than patients in other wards, which showed a statistically significant difference. GGT seems to be a good predictor for the severity of COVID-19. Laboratory data in hospitalized patients with COVID-19, including serum levels of GGT, ALT, and AST, play an essential part in predicting poor outcomes, especially among ICU patients. Key words: Gamma glutamyl transferase, COVID-19, biomarker, systematic review, meta-analysis

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GGT水平作为新冠病毒感染的生物标志物比较重症监护病房(ICU)患者和非ICU患者的系统评价和Meta分析

γ -谷氨酰转移酶(GGT)是一种存在于许多身体器官中的酶，其浓度最高的是肝脏。不同疾病肝损伤后GGT水平升高。本系统综述和荟萃分析旨在评估COVID-19患者的GGT水平，并确定其在诊断疾病严重程度中的预测作用。本系统评价中使用的方法按照PRISMA检查表说明执行。两名独立研究人员检索了国际数据库(PubMed、Web of Science、Scopus和谷歌Scholar)，以查找从COVID-19大流行期间到2021年10月期间发表的相关英文研究。采用Stata软件11 (StataCorp, College Station, TX, USA)进行统计分析。ICU患者血清GGT水平较其他患者高18.19个单位。这一差异具有统计学意义。ICU患者ALT、AST水平高于其他病区，差异有统计学意义。GGT似乎是COVID-19严重程度的一个很好的预测指标。COVID-19住院患者的实验室数据，包括血清GGT、ALT和AST水平，在预测预后不良方面发挥着重要作用，特别是在ICU患者中。关键词:谷氨酰转移酶，COVID-19，生物标志物，系统评价，meta分析

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来源期刊

Infektsionnye Bolezni Medicine-Infectious Diseases

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The journal publishes original research works, reviews of literature, lectures, methodological recommendations, clinical observations. Main topics: problems of etiology, pathogenesis, clinical manifestations of infectious diseases, new techniques and methods of their diagnosis, prevention and treatment; special attention is paid to the problems of antibacterial and antiviral therapy, the use of immunoglobulins and interferons, and also to intensive therapy of critical states. The journal is in the List of leading scientific journals and periodicals of the Supreme Attestation Committee, where the principal results of doctoral dissertations should be published.