Role of the detoxification system in aggravation of pseudotuberculosis and development of complicated disease in children

Q4 Medicine

Infektsionnye Bolezni Pub Date : 2021-01-01 DOI:10.20953/1729-9225-2021-4-37-42

O. L. Nosareva, A. P. Pomogaeva, E. A. Stepovaya, T. V. Zhavoronok, E. V. Shakhristova

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引用次数: 0

Abstract

Objective. To analyze possible role of changes in the level of erythrocyte glutathione S-transferase (GST), serum γ-glutamyltransferase (GGT), and serum 5'-nucleotidase (5'-NT) in aggravation of pseudotuberculosis and development of complicated disease in children, as well as to identify prognostic factors to predict complicated pseudotuberculosis. Patients and methods. This prospective study included 125 children with pseudotuberculosis of different severity and disease course and 45 healthy children (control group). We measured the activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), 5'-NT, GST, GGT, as well as the level of total and conjugated bilirubin. Results. We observed increased levels of ALT, 5'-NT, GST, GGT, and conjugated bilirubin in children with mild and moderate pseudotuberculosis during the acute period, as well as in patients with moderate disease during early convalescence. Children with severe pseudotuberculosis during the acute period and early convalescence demonstrated elevated activity of ALT, AST, 5'-NT, GGT, and maximum increase in the level of bilirubin along with comparable activity of GST. Conclusion. We found that an imbalance of detoxification enzymes in the acute period of pseudotuberculosis has a prognostic value for predicting severe and complicated disease later. Key words: children, pseudotuberculosis, glutathione S-transferase, γ-glutamyltransferase, 5'-nucleotidase

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解毒系统在儿童假性结核加重和复杂疾病发展中的作用

目标。分析红细胞谷胱甘肽s -转移酶(GST)、血清γ-谷氨酰转移酶(GGT)、血清5′-核苷酸酶(5′-NT)水平变化在儿童假性结核病加重及并发疾病发展中的可能作用，并探讨预测并发假性结核病的预后因素。患者和方法。本前瞻性研究纳入125名不同严重程度和病程的假结核患儿和45名健康儿童(对照组)。测定大鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、5′-NT、GST、GGT活性及总胆红素和结合胆红素水平。结果。我们观察到轻度和中度假结核患儿急性期ALT、5′-NT、GST、GGT和结合胆红素水平升高，以及在早期恢复期中度疾病患者。严重假性结核患儿在急性期和恢复期早期表现为ALT、AST、5′-NT、GGT活性升高，胆红素水平显著升高，GST活性相当。结论。我们发现，假性结核急性期解毒酶的失衡对预测以后的严重和复杂疾病具有预测价值。关键词:儿童，假性肺结核，谷胱甘肽s -转移酶，γ-谷氨酰转移酶，5′-核苷酸酶

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来源期刊

Infektsionnye Bolezni Medicine-Infectious Diseases

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The journal publishes original research works, reviews of literature, lectures, methodological recommendations, clinical observations. Main topics: problems of etiology, pathogenesis, clinical manifestations of infectious diseases, new techniques and methods of their diagnosis, prevention and treatment; special attention is paid to the problems of antibacterial and antiviral therapy, the use of immunoglobulins and interferons, and also to intensive therapy of critical states. The journal is in the List of leading scientific journals and periodicals of the Supreme Attestation Committee, where the principal results of doctoral dissertations should be published.