Antibiotic resistance of Moraxella catarrhalis strains isolated from patients with complicated acute respiratory viral infections and other acute respiratory diseases

Q4 Medicine

Infektsionnye Bolezni Pub Date : 2021-01-01 DOI:10.20953/1729-9225-2021-3-85-91

L. Kraeva, O. Burgasova, I. S. Petrova, A. Samoylova, E. Rogacheva, M. Taranova, G. I. Bespalova

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引用次数: 0

Abstract

In recent years, acute respiratory viral infections (ARVIs) and other acute respiratory diseases (ARDs) have acquired some new characteristics of the disease course. The structure of complications has changed, in particular, such complications as community-acquired pneumonia (CAP) and lesions to the upper respiratory tract have become significantly more common. CAP remains one of the main causes of death in patients with ARVIs and other acute respiratory infections due to bacterial resistance to antibiotics. Objective. To assess drug sensitivity of Moraxella catarrhalis strains isolated from patients with complicated ARVIs or ARDs. Materials and methods. Drug susceptibility assessment was performed using the disk diffusion method (DDM) and gradient diffusion method (E-test). The production of β-lactamases was evaluated using nitrocephine, a chromogenic substrate. Results. Isolated strains of M. catarrhalis were resistant to third-generation cephalosporins and sensitive to fourth- and fifthgeneration cephalosporins. More than 70% of M. catarrhalis strains developed resistance to macrolides; 8% of strains were resistant to amoxiclav. All isolated M. catarrhalis strains were sensitive to respiratory fluoroquinolones, carbapenems, and ampicillin-sulbactam. Key words: Moraxella catarrhalis, complications of acute viral infections, bacterial sensitivity to antibiotics

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并发急性呼吸道病毒感染及其他急性呼吸道疾病患者分离的卡他莫拉菌的耐药性研究

近年来，急性呼吸道病毒感染(acute respiratory viral infections, ARVIs)和其他急性呼吸道疾病(acute respiratory diseases, ARDs)的病程出现了一些新的特点。并发症的结构发生了变化，特别是社区获得性肺炎(CAP)和上呼吸道病变等并发症明显增多。由于细菌对抗生素产生耐药性，CAP仍然是ARVIs患者和其他急性呼吸道感染患者死亡的主要原因之一。目标。目的评价从并发ARVIs或ARDs患者中分离的卡他莫拉菌的药物敏感性。材料和方法。采用圆盘扩散法(DDM)和梯度扩散法(e检验)进行药敏评价。利用显色底物硝基萘对β-内酰胺酶的生产进行了评价。结果。分离的卡他菌对第三代头孢菌素耐药，对第四代和第五代头孢菌素敏感。70%以上的卡他氏分枝杆菌对大环内酯类产生耐药性;8%的菌株对阿莫昔拉夫耐药。所有分离的卡他利分枝杆菌对呼吸用氟喹诺酮类药物、碳青霉烯类药物和氨苄西林-舒巴坦敏感。关键词:卡他莫拉菌，急性病毒感染并发症，细菌对抗生素敏感性

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来源期刊

Infektsionnye Bolezni Medicine-Infectious Diseases

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The journal publishes original research works, reviews of literature, lectures, methodological recommendations, clinical observations. Main topics: problems of etiology, pathogenesis, clinical manifestations of infectious diseases, new techniques and methods of their diagnosis, prevention and treatment; special attention is paid to the problems of antibacterial and antiviral therapy, the use of immunoglobulins and interferons, and also to intensive therapy of critical states. The journal is in the List of leading scientific journals and periodicals of the Supreme Attestation Committee, where the principal results of doctoral dissertations should be published.