Analysis of single-nucleotide polymorphisms associated with an increased risk of immune reconstitution inflammatory syndrome in patients with tuberculosis and HIV

Q4 Medicine

Infektsionnye Bolezni Pub Date : 2021-01-01 DOI:10.20953/1729-9225-2021-1-97-104

A. Bukharina, Moscow Russian Federation Human Wellbeing, K. Mironov, V. Zimina

引用次数: 1

Abstract

Tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS) is the development or progression of tuberculosis associated with restoration of active immune response to mycobacteria following the initiation of antiretroviral therapy in HIVinfected patients. The incidence of TB-IRIS is 18% with mortality reaching 2%. Investigation of TB-IRIS in Russia is very important, since the prevalence of TB coinfection is common among HIV-infected patients; in addition to that, HIV is often detected at late stages characterized by severe immunosuppression, which increases the risk of TB-IRIS. This review focuses on single-nucleotide polymorphisms and some other genetic factors associated with an increased risk of TB-IRIS. Key words: antiretroviral therapy, HIV infection, genetic predisposition, single-nucleotide polymorphisms, TB-IRIS, tuberculosis, gene expression

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结核和艾滋病患者免疫重建炎症综合征风险增加的单核苷酸多态性分析

结核免疫重建炎症综合征(TB-IRIS)是指在hiv感染患者开始抗逆转录病毒治疗后，与对分枝杆菌的主动免疫应答恢复相关的结核病的发生或进展。结核病- iris的发病率为18%，死亡率达到2%。俄罗斯结核病- iris调查非常重要，因为结核病合并感染在艾滋病毒感染患者中普遍存在;除此之外，艾滋病毒通常在以严重免疫抑制为特征的晚期才被发现，这增加了结核病- iris的风险。本文综述了与TB-IRIS风险增加相关的单核苷酸多态性和一些其他遗传因素。关键词:抗逆转录病毒治疗，HIV感染，遗传易感性，单核苷酸多态性，TB-IRIS，结核病，基因表达

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来源期刊

Infektsionnye Bolezni Medicine-Infectious Diseases

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The journal publishes original research works, reviews of literature, lectures, methodological recommendations, clinical observations. Main topics: problems of etiology, pathogenesis, clinical manifestations of infectious diseases, new techniques and methods of their diagnosis, prevention and treatment; special attention is paid to the problems of antibacterial and antiviral therapy, the use of immunoglobulins and interferons, and also to intensive therapy of critical states. The journal is in the List of leading scientific journals and periodicals of the Supreme Attestation Committee, where the principal results of doctoral dissertations should be published.