Clinical, epidemiological and etiological features of severe acute respiratory infections in hospitalized patients

Q4 Medicine

Infektsionnye Bolezni Pub Date : 2021-01-01 DOI:10.20953/1729-9225-2021-1-64-70

S. S. Smirnova, Ekaterinburg Russian Federation Human Well-being, E. V. Lelenkova, A. Markaryan, I. V. Vyalykh, A. V. Alimov

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Abstract

Objective. To study the clinical, epidemiological and etiological characteristics of severe acute respiratory infections (SARI) in in-patients in Ekaterinburg during the epidemic season 2017–2018. Patients and methods. 403 individual medical records were studied. Etiological decoding was carried out by isolating RNA or DNA of respiratory viruses from nasopharyngeal swabs by polymerase chain reaction. Results. SARI in hospitalized patients were caused by both influenza viruses (В Yamagata – 25.2% and А(H1N1)pdm09 – 11.0%) and viruses of non-influenza etiology (respiratory syncytial virus (RS-virus) – 13.3%, rhinovirus – 12.9%, metapneumovirus – 11.0%). It was found that viruses were more often secreted in children than in adults; among children of the younger age group (0–2 years old) viruses of non-influenza etiology were detected significantly more often, and in children 7–14 years old, influenza viruses were more often isolated. Patients with upper respiratory tract infections were significantly more likely to have influenza viruses (78.9%) than patients with lower respiratory tract infections (21.1%). Conclusion. The results of the study indicate the importance of hospital surveillance for SARI from the point of view of the etiological diagnosis of respiratory infections, the study of epidemiology and typical clinical manifestations for the timely diagnosis and development of additional preventive and anti-epidemic measures. Key words: hospital surveillance, influenza, PCR diagnostics, respiratory infections, epidemiology, etiology

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住院患者严重急性呼吸道感染的临床、流行病学和病因学特征

目标。目的研究2017-2018年流行季叶卡捷琳堡市住院患者严重急性呼吸道感染(SARI)的临床、流行病学和病因学特征。患者和方法。研究了403份个人医疗记录。采用聚合酶链反应从鼻咽拭子中分离呼吸道病毒RNA或DNA，进行病原学解码。结果。住院患者SARI由流感病毒(В Yamagata - 25.2%和А(H1N1)pdm09 - 11.0%)和非流感病原学病毒(呼吸道合胞病毒(RS-virus) - 13.3%，鼻病毒- 12.9%，偏肺病毒- 11.0%)引起。研究发现，儿童体内分泌的病毒比成人多;在较年轻年龄组(0-2岁)的儿童中，检测到非流感病因的病毒的频率明显更高，而在7-14岁的儿童中，流感病毒的分离率更高。上呼吸道感染患者感染流感病毒的可能性(78.9%)明显高于下呼吸道感染患者(21.1%)。结论。研究结果表明，从呼吸道感染的病原学诊断、流行病学研究和典型临床表现的角度来看，医院监测对于及时诊断和制定额外的预防和防疫措施具有重要意义。关键词:医院监测，流感，PCR诊断，呼吸道感染，流行病学，病因学

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来源期刊

Infektsionnye Bolezni Medicine-Infectious Diseases

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The journal publishes original research works, reviews of literature, lectures, methodological recommendations, clinical observations. Main topics: problems of etiology, pathogenesis, clinical manifestations of infectious diseases, new techniques and methods of their diagnosis, prevention and treatment; special attention is paid to the problems of antibacterial and antiviral therapy, the use of immunoglobulins and interferons, and also to intensive therapy of critical states. The journal is in the List of leading scientific journals and periodicals of the Supreme Attestation Committee, where the principal results of doctoral dissertations should be published.