Comprehensive evaluation of the effectiveness of gluten-free casein-free diet in children with delayed psycho-speech development

Q3 Medicine
L. Khachatryan, E. V. Kasanave, N. Geppe, E. Tyurina, T.S. Kaminskaya, D.E. Vadiyan, A. V. Polyanskaya, S. Chebysheva, M. Manukyan
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引用次数: 1

Abstract

Objective. To justify the significance of using a gluten-free casein-free diet (GFCF diet) in children with delayed psycho-speech development (DPSD) and to study its effect on the somatic and neuropsychological status of these patients. Patients and methods. This randomized, open-label, prospective trial involved 105 children (71 boys and 34 girls) with DPSD between the ages of 1 year 6 months and 6 years 7 months. Children were divided into two groups: group 1 included 53 children who received the GFCF diet; group 2 – 52 children who ate regular meals. Children were examined at the beginning of observation, after 6 and 12 months. We used the Integrative Medicine Assessment Scale (IMAS) 1 and 2, Childhood Autism Rating Scale, Autism Treatment Evaluation Checklist (ATEC), Integrative Medicine Patients Parent Scale. Laboratory and instrumental examinations included blood tests for antibodies IgA, IgM, IgG, IgE, Anti-tTG IgA, Anti-tTG IgG, Anti-EMA, stool tests for calprotectin and zonulin, ultrasound imaging of the abdomen, kidney, heart, transcranial Doppler ultrasound of brain vessels, and magnetic resonance imaging of the brain if necessary. All children were examined by a neurologist, psychiatrist, geneticist, and surdologist. Results. A significant effectiveness of the GFCF diet in children with DPSD, including autism spectrum disorders, was justified. It was shown that the number of children without stereotypic movement disorders, as well as without digestive problems, increased by 1.5 and 2.3 times in the group of patients receiving diet therapy compared to the group without dietary correction after 6 and 12 months from the beginning of observation; the proportion of highly expressed stereotypies decreased by 2.3 times after 6 months. According to the ATEC scale, the number of children with severe disorders was 2.2 and 2.9 times lower after 6 and 12 months, respectively; according to the somatic status assessment scale (IMAS), the total score was 1.25 times lower. Conclusion. The GFCF diet has a positive effect on the neuropsychological and somatic status of children with DPSD. Children with DPSD have non-celiac gluten sensitivity, in which adherence to the diet allows to alleviate gastrointestinal and neurological manifestations. Key words: anti-tissue transglutaminase antibodies, autism, gluten-free diet, delayed psycho-speech development
无麸质无酪蛋白饮食对心理语言发育迟缓儿童的有效性的综合评价
目标。目的探讨无谷蛋白无酪蛋白饮食(GFCF饮食)对儿童心理语言发育迟缓(DPSD)的意义,并研究其对这些患者躯体和神经心理状态的影响。患者和方法。这项随机、开放、前瞻性的试验纳入了105名患有DPSD的儿童(71名男孩和34名女孩),年龄在1岁6个月至6岁7个月之间。儿童被分为两组:第一组包括53名接受GFCF饮食的儿童;第二组- 52名正常饮食的儿童。在观察开始、6个月和12个月后对儿童进行检查。采用中西医结合评估量表(IMAS) 1、2、儿童自闭症评定量表、自闭症治疗评估表(ATEC)、中西医结合患者家长量表。实验室和仪器检查包括血液IgA、IgM、IgG、IgE、Anti-tTG IgA、Anti-tTG IgG、Anti-EMA,大便钙保护蛋白和zonulin检查,腹部、肾脏、心脏超声检查,血管经颅多普勒超声检查,必要时进行脑磁共振成像。所有儿童均由神经科医生、精神科医生、遗传学家和外科医生进行检查。结果。GFCF饮食对包括自闭症谱系障碍在内的DPSD儿童的显著有效性得到了证明。结果表明,在观察开始6个月和12个月后,接受饮食治疗的儿童中,无刻板运动障碍和无消化问题的儿童数量比未接受饮食纠正的儿童增加了1.5倍和2.3倍;6个月后,高度表达的刻板印象比例下降了2.3倍。根据ATEC量表,6个月和12个月后出现严重障碍的患儿数量分别减少2.2倍和2.9倍;根据躯体状态评定量表(IMAS),总得分降低1.25倍。结论。GFCF饮食对DPSD儿童的神经心理和躯体状态有积极影响。患有DPSD的儿童对非乳糜泻麸质敏感,在这种情况下,坚持饮食可以减轻胃肠道和神经系统症状。关键词:抗组织转谷氨酰胺酶抗体;自闭症;无麸质饮食
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来源期刊
Voprosy Detskoi Dietologii
Voprosy Detskoi Dietologii Medicine-Pediatrics, Perinatology and Child Health
CiteScore
1.20
自引率
0.00%
发文量
17
期刊介绍: The scientific journal Voprosy Detskoi Dietologii is included in the Scopus database. Publisher country is RU. The main subject areas of published articles are Food Science, Pediatrics, Perinatology, and Child Health, Nutrition and Dietetics, Клиническая медицина.
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