Total Hip Arthroplasty in Sickle Cell Disease

Abstract

Sickle cell disease (SCD) is a hemoglobinopathy characterized by abnormal morphology of blood cells causing transient interruption of blood supply to various body parts. Femoral Head avascular necrosis is one of the commonest skeletal sequeale of SCD. Total Hip arthroplasty (THA) in SCD has evolved through different stages with a spectrum of results and technical challenges. This article reviews the pathologic basis of sickle cell disease , the various challenges perioperatively associated with THA in SCD.