Resveratrol Attenuates Heat-Stress-Impaired Immune and Inflammatory Responses of Broilers by Modulating Toll-Like Receptor-4 Signaling Pathway

IF 1.1 4区 农林科学 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Z. Li, A. Liu, J. Xu, C. Zhang
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引用次数: 0

Abstract

This study investigated the effect of resveratrol on the immune and inflammatory responses and the mRNA levels of splenic toll-like receptor (TLR)-4 signaling pathway-related genes of broilers under heat stress (HS). One hundred and sixty-two birds were allocated to three groups, each with 6 replicates, for 21 continuous days. The three treatments were as follows: the control group (22 ± 1 °C), the HS (33 ± 1 °C for 10 h d -1 and 22 ± 1 °C for the remaining time) group and the HS + resveratrol (400 mg kg -1 ) group. At the end of the trial, one bird per replicate close to the average body weight (BW) was selected, exsanguinated, and slaughtered. Compared with the control group, the HS treatment decreased ( p <0.05) final BW, average daily gain (ADG), average daily feed intake (ADFI), relative weight of bursa of Fabricius and spleen, serum immunoglobulin (Ig) Y, IgA and interleukin (IL)-10 contents, and splenic IL-10 mRNA level, while it increased ( p <0.05) feed/gain, mRNA levels of splenic tumor necrosis factor-α (TNF-α ), TLR-4, nuclear factor-kappa-B (NF-κ B), IL-1 β , and IL-6. Compared to the HS group, the HS+resveratrol group exhibited increased ( p <0.05) final BW, ADG, relative weight of bursa of Fabricius and spleen, serum IgY, IgA and IL-10 contents, and splenic IL-10 mRNA level, while it exhibited lower ( p <0.05) TNF-α , IL-1 β and IL-6 contents in serum, and splenic TLR4, TNF-α , IL-1 β , and NF-κ B mRNA levels. In conclusion, resveratrol prevented a HS-impairment of the immune function of broilers by blocking the abnormal activation of the TLR4 signaling pathway.
白藜芦醇通过调节toll样受体-4信号通路减轻热应激损伤肉鸡的免疫和炎症反应
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来源期刊
Brazilian Journal of Poultry Science
Brazilian Journal of Poultry Science 农林科学-奶制品与动物科学
CiteScore
1.80
自引率
9.10%
发文量
60
审稿时长
>12 weeks
期刊介绍: A Revista Brasileira de Ciência Avícola surgiu em 1999 a partir da necessidade que a comunidade científica possuía de um periódico para veiculação e publicação de seus trabalhos, com a publicação de três números anuais. A Revista conta hoje com um corpo editorial altamente qualificado e com artigos científicos desenvolvidos pelos maiores especialistas da área, o que a cada dia atrai mais leitores em busca de inovação e respaldo técnico. Devido à credibilidade que conquistou pelos esforços de sus autores, relatores e revisores, a Revista ganhou caráter de coleção, sendo consultada como fonte segura de estudo desenvolvidos na Avicultura. A partir de 2003 – volume 5 -, a Revista passou a chamar-se Brazilian Journal of Poultry Science, e todos os trabalhos passaram a ser publicados em inglês. No mesmo ano subiu para quatro o número de revistas por volume, ampliando-se assim os trabalhos publicados anualmente.
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