Clinico-pathological and immunohistochemical findings in a case of bovine cutaneous angiomatosis in a Holstein heifer

IF 0.8 4区农林科学 Q3 AGRONOMY

Ciencia Rural Pub Date : 2023-04-14 DOI:10.1590/0103-8478cr20220502

Liz de Albuquerque Cerqueira, D. E. Sousa, I. Macêdo, A. S. Silva, A. Câmara, C. B. Melo, M. B. Castro

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Abstract

ABSTRACT: Bovine cutaneous angiomatosis (BCA) is a rare condition characterized by vasoproliferative skin lesions mainly affecting cattle in the northern hemisphere. An eight-month-old Holstein heifer showed two skin easy-bleeding nodules bulging from the epidermis in the forehead and close to the right prescapular region. Skin lesions were within the dermis and had an irregular surface and a soft heterogeneous reddish parenchyma composed of numerous variable-sized arterioles, veins, and capillaries surrounded by abundant collagenous fibrous tissue. Immunohistochemical assays evidenced endothelial cells lining proliferative vascular structure immunolabeled for CD31 and Von Willebrand factor, and vascular smooth muscle cells immunostained for smooth muscle actin. All clinical, pathological, and immunohistochemical features observed in the Holstein heifer were hallmarks of BCA. Considering its potential for hereditary spread, BCA must be included in the differential diagnosis of easily bleeding skin nodules that do not respond to routine topical wound treatments to prevent its spread in Brazilian herds.

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1例荷斯坦小母牛皮肤血管瘤病的临床病理和免疫组织化学结果

摘要:牛皮肤血管瘤病(BCA)是一种以血管增生性皮肤病变为特征的罕见疾病，主要发生在北半球的牛。一只8个月大的荷斯坦小母牛在前额靠近右包膜前区域的表皮处出现两个易出血的皮肤结节。皮肤病变位于真皮层内，表面不规则，软而不均匀的红色实质由许多大小不等的小动脉、静脉和毛细血管组成，周围有丰富的胶原纤维组织。免疫组化检测证实，内皮细胞在增生性血管结构中被CD31和血管性血液病因子免疫标记，血管平滑肌细胞被平滑肌肌动蛋白免疫标记。在荷斯坦小母牛中观察到的所有临床、病理和免疫组织化学特征都是BCA的标志。考虑到其遗传传播的可能性，BCA必须包括在易出血的皮肤结节的鉴别诊断中，这些结节对常规局部伤口治疗无效，以防止其在巴西畜群中传播。

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来源期刊

Ciencia Rural AGRONOMY-

CiteScore

1.70

自引率

0.00%

发文量

233

审稿时长

2-4 weeks

期刊介绍： The purpose of Ciência Rural is to publish the results of original research, note and reviews which contribute significantly to knowledge in Agricultural Sciences. Preference will be given to original articles that develop news concepts or experimental approaches and are not merely repositories of scientific data. The decison of acceptance for publication lies with the Editors and is based on the recommendations of Editorial Comission, Area Committee and/ or ad hoc reviewers. The editors and reviewers are external to the institution.