Proton Pump Inhibitor Use and Risk of Dementia in Older Adults: A Systematic Review

Xiaoyi Gao, Z. Shao, N. Grysman, G. Grossberg
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引用次数: 1

Abstract

Proton pump inhibitors (PPIs) are commonly used for gastroesophageal reflux disease. Previous studies have raised concerns about the impact of PPIs on cognition in older adults, but the evidence supporting this concern is lacking. This article aims to analyse the available data regarding the impact of long-term PPI use on cognition in older adults. We searched PubMed for relevant studies conducted between 2015 and 2022. Seventeen such studies were identified. Limitations to available research data include the fact that studies are mainly observational, use heterogeneous study methods and do not account for confounding variables such as B12 deficiency, Helicobacter pylori infection, and thyroid dysfunction. Overall, this search did not find a compelling association between PPI use and cognitive decline.
质子泵抑制剂的使用和老年人痴呆的风险:一项系统综述
质子泵抑制剂(PPIs)常用于胃食管反流病。先前的研究提出了PPIs对老年人认知能力影响的担忧,但缺乏支持这一担忧的证据。本文旨在分析关于长期使用PPI对老年人认知影响的现有数据。我们在PubMed检索了2015年至2022年间进行的相关研究。17个这样的研究被确认。现有研究数据的局限性包括研究主要是观察性的,使用异质研究方法,并且没有考虑诸如B12缺乏、幽门螺杆菌感染和甲状腺功能障碍等混杂变量。总的来说,这项研究并没有发现PPI使用和认知能力下降之间存在令人信服的联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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