Exploring the Impact of Coronavirus Disease 2019 on Dementia: A Review

Michael Axenhus, B. Winblad
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Abstract

The coronavirus disease 2019 (COVID-19) pandemic has caused significant disruptions to almost every healthcare system worldwide. Older adults have been hit disproportionately hard by the pandemic, with most deaths occurring among people aged 75 or older. Dementia researchers have noted the increased dementia-related mortality among older adults and fewer dementia diagnoses during the pandemic. Questions have therefore been raised regarding the effects of the COVID-19 virus on dementia prevalence and mortality. As a groundbreaking dementia treatment is about to hit the market, proper diagnoses of dementia are now more important than ever. There are also concerns that the COVID-19 virus could precipitate dementia and worsen dementia symptoms. This short review examines the current scientific evidence on the impact of COVID-19 on dementia mortality and prevalence, as well as describing the pathophysiological mechanisms by which COVID-19 might cause dementia and worsen dementia symptoms. Lastly, this review speculates on how dementia epidemiology might change during the next years as a result of the pandemic and provide suggestions for clinicians on how to respond to the coming changes.
探索2019冠状病毒病对痴呆症的影响:综述
2019冠状病毒病(COVID-19)大流行对全球几乎所有医疗保健系统都造成了严重破坏。老年人受到大流行的打击尤为严重,大多数死亡发生在75岁或以上的人群中。痴呆症研究人员注意到,在大流行期间,老年人与痴呆症相关的死亡率增加,痴呆症诊断减少。因此,人们提出了关于COVID-19病毒对痴呆症患病率和死亡率的影响的问题。随着一种突破性的痴呆症治疗方法即将上市,对痴呆症的正确诊断现在比以往任何时候都更加重要。还有人担心,新冠病毒可能会引发痴呆症,并使痴呆症症状恶化。这篇简短的综述审查了目前关于COVID-19对痴呆症死亡率和患病率影响的科学证据,并描述了COVID-19可能导致痴呆症和加重痴呆症症状的病理生理机制。最后,这篇综述推测了痴呆症流行病学在未来几年可能会因大流行而发生的变化,并为临床医生提供了如何应对即将发生的变化的建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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