Siponimod—A Selective Sphingosine-1-phosphate Modulator for Secondary Progressive Multiple Sclerosis

Abstract

Over the past decade, there has been a rapid expansion of disease-modifying therapies for multiple sclerosis (MS), which exhibit a variety of different mechanisms of action. While the non-selective sphingosine-1-phosphate (S1P) receptor modulator fingolimod has been available for a decade, two novel selective S1P receptor modulators, siponimod and ozanimod, have been recently approved by the US Food and Drug Adminstration for use in "active" secondary progressive MS (SPMS). Siponimod, the subject of this article, is the only S1P receptor modulator studied in both relapsing remitting MS and SPMS. In this article, we review the clinical trial data regarding use of this medication and the implications for use in patients with SPMS.