Pediatric Anaplastic Large Cell Lymphoma—A Review

IF 0.7 1区历史学 Q1 HISTORY

Oral History Review Pub Date : 2018-01-01 DOI:10.17925/OHR.2018.14.1.21

Soumitra Tole, Laura Wheaton, S. Alexander

引用次数: 4

Abstract

Anaplastic large cell lymphoma (ALCL) is the most common pediatric peripheral T-cell lymphoma, accounting for 10–15% of pediatric non-Hodgkin lymphoma. Patients with pediatric ALCL commonly present at an advanced stage of disease and, unlike adult ALCL, the majority of pediatric cases demonstrate overexpression of anaplastic lymphoma kinase (ALK). Despite a range of treatment strategies, event-free survival has remained stagnant at 65–75%. The role of novel targeted therapies such as ALK inhibitors and anti-CD30 antibody drug conjugates are actively being studied in both the newly diagnosed and relapse setting. This review article will cover the pathology, clinical presentation, and prognostic factors for pediatric ALCL, and will focus on a discussion of the therapeutic strategies for this disease.

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儿童间变性大细胞淋巴瘤a综述

间变性大细胞淋巴瘤(ALCL)是最常见的儿童外周t细胞淋巴瘤，占儿童非霍奇金淋巴瘤的10-15%。儿童ALCL患者通常出现在疾病的晚期，与成人ALCL不同，大多数儿童病例表现出间变性淋巴瘤激酶(ALK)的过度表达。尽管有一系列的治疗策略，无事件生存率仍然停滞在65-75%。新的靶向治疗如ALK抑制剂和抗cd30抗体药物偶联物在新诊断和复发环境中的作用正在积极研究中。这篇综述文章将涵盖儿科ALCL的病理、临床表现和预后因素，并将重点讨论这种疾病的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral History Review Multiple-

CiteScore

1.20

自引率

27.30%

发文量

期刊介绍： The Oral History Review, published by the Oral History Association, is the U.S. journal of record for the theory and practice of oral history and related fields. The journal’s primary mission is to explore the nature and significance of oral history and advance understanding of the field among scholars, educators, practitioners, and the general public. The Review publishes narrative and analytical articles and reviews, in print and multimedia formats, that present and use oral history in unique and significant ways and that contribute to the understanding of the nature of oral history and memory. It seeks previously unpublished works that demonstrate high-quality research and that offer new insight into oral history practice, methodology, theory, and pedagogy. Work published in the journal arises from many fields and disciplines, reflecting the interdisciplinary nature of oral history. While based in the U.S., the Review reflects the international scope of the field and encourages work from international authors and about international topics.