Triple negative breast cancer-review of current and emerging therapeutic strategies

IF 0.7 1区 历史学 Q1 HISTORY
T. Ballinger, J. Kremer, K. Miller
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引用次数: 14

Abstract

T riple negative breast cancer (TNBC) is associated with a poor prognosis compared to other types of breast cancer. The classification of 'triple negative' is not one homogenous tumor type, but rather is made up of multiple molecularly and biologically diverse tumor subtypes. At present, no approved targeted therapy exists and the standard remains cytotoxic chemotherapy. The identification of TNBC subtypes has provided a basis for identifying possible targeted therapeutic options. In addition, the recognition that some TNBCs share characteristics similar to tumors arising in patients with germline BRCA mutations has led to consideration of DNA damaging agents as a potential treatment option. Multiple investigational approaches are also underway, including immune checkpoint inhibition, poly (ADP-ribose) polymerase inhibition, and androgen receptor blockage. The limited options available for systemic treatment of TNBC will hopefully expand as more is learned about the complex biology and molecular targets of this group of breast cancers. This review will discuss the biology of TNBC, current treatment options, and promising experimental strategies.
三阴性乳腺癌-当前和新出现的治疗策略综述
与其他类型的乳腺癌相比,T型阴性乳腺癌(TNBC)的预后较差。“三阴性”的分类不是一种同质的肿瘤类型,而是由多种分子和生物多样性的肿瘤亚型组成。目前,还没有被批准的靶向治疗方法,标准仍然是细胞毒性化疗。TNBC亚型的鉴定为确定可能的靶向治疗方案提供了基础。此外,由于认识到某些tnbc具有与种系BRCA突变患者肿瘤相似的特征,因此考虑使用DNA损伤剂作为潜在的治疗选择。多种研究方法也在进行中,包括免疫检查点抑制、聚(adp -核糖)聚合酶抑制和雄激素受体阻断。随着对这类乳腺癌复杂的生物学和分子靶点的更多了解,有限的全身治疗方案有望扩大。这篇综述将讨论TNBC的生物学,目前的治疗方案,和有前途的实验策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.20
自引率
27.30%
发文量
33
期刊介绍: The Oral History Review, published by the Oral History Association, is the U.S. journal of record for the theory and practice of oral history and related fields. The journal’s primary mission is to explore the nature and significance of oral history and advance understanding of the field among scholars, educators, practitioners, and the general public. The Review publishes narrative and analytical articles and reviews, in print and multimedia formats, that present and use oral history in unique and significant ways and that contribute to the understanding of the nature of oral history and memory. It seeks previously unpublished works that demonstrate high-quality research and that offer new insight into oral history practice, methodology, theory, and pedagogy. Work published in the journal arises from many fields and disciplines, reflecting the interdisciplinary nature of oral history. While based in the U.S., the Review reflects the international scope of the field and encourages work from international authors and about international topics.
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