Mind-Body Interventions Significantly Decrease Oxidative DNA Damage in Sperm Genome: Clinical Implications

Reactive oxygen species (Apex, N.C.) Pub Date : 2019-01-01 DOI:10.20455/ROS.2019.801

V. Dhawan, Manoj Kumar, P. Chaurasia, R. Dada

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引用次数: 2

Abstract

Mind-body interventions (MBIs) have been broadly categorized into a group of interventions which facilitate mind’s capacity to affect the functions of the body. There is a growing body of evidence suggesting the adoption of MBIs like yoga, meditation, Tai Chi, and Qigong as an adjunct in the management of various complex lifestyle-related disorders. This review summarizes the importance of simple yoga- and meditation-based lifestyle intervention as a critical component of male infertility therapy. Defective chromatin integrity is one of the hallmarks of male factor infertility. Regular practice of yoga and meditation affects and targets the whole body, decreases free radical levels, and causes collateral increase in levels of antioxidants, not only resulting in improvement in standard sperm parameters, but also becoming ideal in treating oxidative stress and oxidative DNA damage and modulating levels of sperm transcripts through affecting the sperm methylome. This may aid in reversing testicular aging and improving the overall health and quality of life of male infertility patients and of the next generation.

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心身干预显著降低精子基因组氧化性DNA损伤:临床意义

身心干预(mbi)被广泛地归类为一组干预，这些干预促进了心灵影响身体功能的能力。越来越多的证据表明，瑜伽、冥想、太极和气功等mbi可以作为治疗各种复杂生活方式相关疾病的辅助手段。这篇综述总结了简单的瑜伽和冥想为基础的生活方式干预作为男性不育症治疗的关键组成部分的重要性。染色质完整性缺陷是男性因素不育的标志之一。定期练习瑜伽和冥想影响并针对整个身体，降低自由基水平，并导致抗氧化剂水平的附带增加，不仅导致标准精子参数的改善，而且在治疗氧化应激和氧化DNA损伤以及通过影响精子甲基组调节精子转录物水平方面也变得理想。这可能有助于扭转睾丸老化，改善男性不育症患者和下一代的整体健康和生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Reactive oxygen species (Apex, N.C.)

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