Conductometric Titration of Metformin Hydrochloride: Simulation and Experimentation

Abstract

In order to teach students, the importance of conductometric titrations in this work, we present a laboratory experiment to quantify the amount of metformin hydrochloride in a tablet. The quantification was carried out through the evaluation of the chloride by silver nitrate. The titration and the end point were followed by conductometric titration, as well as by potentiometric and visually by the Volhard method. In addition, the theoretical conductivities of the metformin hydrochloride solution were calculated when known volumes of titrant are added, using the limit conductivity data for each of the ions present in the literature. To simulate the conductometric titration, the calculated conductivity values were plotted based on the volume of silver nitrate added. A comparison between techniques is made in order to determine the best monitoring method, being this one conductimetry to detect the equivalence point for metformin hydrochloride with 0.99±0.03, according to relative standard deviation (% RSD). Simulated titration curves adequately describe obtained results in an experimental way. The conductometric titration is the best method for quantification since it shows less dispersion between obtained results and has the highest concordance among results. Their application is shown through the analysis and conductometric titration simulations.