Clinical, histopathological, and hematological changes due to isoimmune thrombocytopenic purpura in piglets

IF 0.8 4区 农林科学 Q3 VETERINARY SCIENCES
J. C. O. Menegatt, Amauri Rigo, M. Mezaroba, A. Ramos, C. Gamba, Carolina Reck, Á. Menin
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Abstract

ABSTRACT: Isoimmune thrombocytopenic purpura (ITP) is an immune-mediated disease that causes severe hemorrhagic lesions and high mortality in piglets. The disease can occur early in newborn piglets (EITP) or late in 2- to 3-week old piglets (LITP). In this study, we analysed the clinical, pathological, and hematological aspects of 391 ITP cases (312 with EITP and 79 with LITP). In LIPT cases, morbidity and mortality rates were higher, with rates of 60% (morbidity) and 53% (mortality). The main clinicopathological findings in ITP cases were different patterns of hemorrhages organs and tissues. In EITP, clinical signs were characterized by extensive subcutaneous hemorrhages and death occurred within a few days; however, in LITP, often sudden death occurred. In macroscopic analysis, hemorrhagic diathesis was observed in all affected animals. In EITP, the most severe hemorrhagic lesions were integumentary, mainly in the dermis and epidermis. In LITP, visceral lesions were predominant, mainly in the epicardium and intestines. Microscopic bone marrow analysis revealed mild cellular hyperplasia in EITP and bone marrow aplasia in LITP. hematological analyses revealed leucopenia, thrombocytopenia, and anemia in all ITP-affected animals. However, fostering by a different sow was only efficient in controlling EITP and had little effect in LITP-symptomatic piglets, due to more severe lesions. Further studies on the etiopathogenesis of LITP are required to improve our understanding of this disease form.
仔猪等免疫血小板减少性紫癜的临床、组织病理学和血液学改变
摘要:等免疫血小板减少性紫癜(ITP)是一种免疫介导的疾病,可引起仔猪严重的出血性病变和高死亡率。该病可发生在新生仔猪早期(EITP)或2至3周龄仔猪晚期(LITP)。在这项研究中,我们分析了391例ITP的临床、病理和血液学方面的问题(312例EITP和79例LITP)。在LIPT病例中,发病率和死亡率更高,分别为60%(发病率)和53%(死亡率)。ITP病例的主要临床病理表现为脏器和组织出血类型不同。EITP的临床症状以大面积皮下出血和数日内死亡为特征;然而,在LITP中经常发生猝死。肉眼观察,所有患病动物均有出血性。在EITP中,最严重的出血性病变是表皮,主要在真皮和表皮。在LITP中,以内脏病变为主,主要在心外膜和肠。显微镜下骨髓分析显示EITP轻度细胞增生,LITP骨髓发育不全。血液学分析显示,所有itp影响的动物都有白细胞减少、血小板减少和贫血。然而,不同母猪的饲养只对控制EITP有效,对有litp症状的仔猪效果不大,因为病变更严重。需要进一步研究LITP的发病机制,以提高我们对这种疾病形式的认识。
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来源期刊
Pesquisa Veterinaria Brasileira
Pesquisa Veterinaria Brasileira 农林科学-兽医学
CiteScore
1.30
自引率
16.70%
发文量
41
审稿时长
9-18 weeks
期刊介绍: Pesquisa Veterinária Brasileira - Brazilian Journal of Veterinary Research (http://www.pvb.com.br), edited by the Brazilian College of Animal Pathology in partnership with the Brazilian Agricultural Research Organization (Embrapa) and in collaboration with other veterinary scientific associations, publishes original papers on animal diseases and related subjects. Critical review articles should be written in support of original investigation. The editors assume that papers submitted are not being considered for publication in other journals and do not contain material which has already been published. Submitted papers are peer reviewed. The abbreviated title of Pesquisa Veterinária Brasileira is Pesqui. Vet. Bras.
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