The Treatment of Depression with Newer Antidepressants: Pharmacology and Efficacy Versus Clinical Effectiveness

Abstract

OBJECTIVE: To describe the pharmacological mechanisms of recently introduced antidepressants that is assumed to contribute to their efficacy. DATA SOURCES: Literature references. CONCLUSION: Although controlled clinical trials have shown new antidepressant agents. to be as efficacious as traditional agents, their potential to result in improved patient outcomes may translate into a better cost-effectiveness ratio.