Understanding of “-omics” of Parkinson’s disease

Abstract

Parkinson’s Disease (PD), as one neurodegenerative disease, reduce the life quality of our patients extensively. Since the identification and validation of role of alpha-synuclein in PD, several impactful hypotheses pointed out the direction of our research, while the bioinformatic studies initialized to focus on the generation, formation, transportation and aberrant clearance of alpha-synuclein. The pioneer studies of Braak provided a comprehensive classification between alpha-synuclein and the severity of PD. Currently our understanding of bioinformatic on PD are increasing sharply as well from genomic, proteomic and metabolomic. To our best knowledge, here we provide a comprehensive picture of this disease from genomic to metabolomic.