Un-functionalized Gold Nanoparticles as a Simple Colorimetric Probe for Sensitive and Selective Detection of Dopamine

IF 0.8 4区 化学 Q4 CHEMISTRY, MULTIDISCIPLINARY
Nokuthula Khanyile, R. Krause, Sibulelo L. Vilakazi, N. Torto
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引用次数: 2

Abstract

A dopamine (DA) colorimetric probe based on the growth and aggregation of un-functionalized gold nanoparticles (AuNPs) is reported. Upon addition of AuNPs to dopamine at various concentrations, the shape, size and colour change of the nanoparticles results in spectral shifts to higher wavelengths and hence colour change is the mode of detection. The colour change can be easily observed by the naked eye from as low as 5.0 nM DA, even under sub-optimal conditions. Under optimal pH conditions the calculated limit of detection was 2.5 nM (3ó). The probe was successfully applied to whole blood sample and showed good selectivity and sensitivity towards DA. The simple, sensitive and selective probe could be an excellent alternative for on-site and immediate detection of DA without the use of instrumentation and would thus be useful for rapid diagnostic applications.
非功能化金纳米颗粒作为一种简单的比色探针用于多巴胺的敏感和选择性检测
报道了一种基于非功能化金纳米颗粒(AuNPs)生长和聚集的多巴胺(DA)比色探针。在多巴胺中加入不同浓度的AuNPs后,纳米颗粒的形状、大小和颜色变化导致光谱向更高波长移动,因此颜色变化是检测模式。即使在次优条件下,也可以很容易地用肉眼观察到低至5.0 nM DA的颜色变化。在最佳pH条件下,计算检出限为2.5 nM (3ó)。该探针成功地应用于全血样品,对DA具有良好的选择性和敏感性。该探针简单、灵敏、选择性好,可作为现场和即时检测DA的极好选择,无需使用仪器,因此可用于快速诊断应用。
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来源期刊
CiteScore
3.10
自引率
0.00%
发文量
6
审稿时长
>12 weeks
期刊介绍: Original work in all branches of chemistry is published in the South African Journal of Chemistry. Contributions in English may take the form of papers, short communications, or critical reviews.
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