The Eosinophil: Physiology and Pathology

Clinical research and trials Pub Date : 2020-01-01 DOI:10.15761/crt.1000287

A. Alvarado

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引用次数: 2

Abstract

The knowledge of these intriguing cells has gone through various phases since their description. They were originally considered as inflammatory, but protective cells. Subsequently, its potential pathological impact was discovered under various conditions, ranging from antiparasitic and allergic effects to autoimmune, neoplastic, inflammatory and idiopathic disorders. New visions of the molecular basis of the development and traffic of eosinophils and their vigorous participation in the immune regulation circuit define them as very active immune cells, but their ability to invade tissues and their powerful enzyme arsenal place them as effector cells with increased potential inflammatory and cytotoxic. The knowledge of their immunomodulatory activity and their participation in various pathologies has allowed us to design new therapeutic strategies that impact their function in various nosological entities. This monograph aims to update the knowledge of its physiology and associated disorders and diseases. *Correspondence to: Alcibey Alvarado. Clínica de Diagnóstico Médico. Torre Médica. 3 piso. Paseo Colón, San José, Costa Rica, Tel: 50622237134; 50622566439; 50687351858; Fax: 50622216754; E-mail: alcialvagonza@yahoo.com.mx

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嗜酸性粒细胞:生理学和病理学

自从这些有趣的细胞被描述以来，人们对它们的认识经历了不同的阶段。它们最初被认为是炎症细胞，但实际上是保护细胞。随后，其潜在的病理影响在各种情况下被发现，从抗寄生虫和过敏作用到自身免疫、肿瘤、炎症和特发性疾病。嗜酸性粒细胞的分子基础的发展和运输及其在免疫调节回路中的积极参与的新视角将它们定义为非常活跃的免疫细胞，但它们入侵组织的能力和强大的酶库使它们成为具有增加潜在炎症和细胞毒性的效应细胞。了解它们的免疫调节活性及其参与各种病理，使我们能够设计新的治疗策略，影响它们在各种疾病实体中的功能。本专著旨在更新其生理学和相关疾病的知识。*通讯:Alcibey Alvarado。Clínica de Diagnóstico msamadico。托瑞》。3庇索。哥斯达黎加圣何塞大道Colón，电话:50622237134;50622566439;50687351858;传真:50622216754;电子邮件:alcialvagonza@yahoo.com.mx

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Clinical research and trials

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