Bir pandemi hastanesi Acil servisinde Covid-19 Hastaların C-Reaktif protein/Albümin Oranının Klinik Önemi

Abstract

Aim: To investigate the prognostic significance of the C-reactive protein-to-albumin ratio (CAR) in coronavirus disease 2019 (COVID-19) patients admitted for the first time to a hospital emergency department (ED). Materials and methods: The study we report herein was a single-center, prospective observational study. A total of 745 participants (385 patients, 360 individuals) were included in the study. The CAR was calculated by dividing the C-reactive protein (CRP; mg/L) value by the albumin value (gr). The data were analyzed using MedCalc Statistical Software v12.7.0.0 (Ostend, Belgium) and Student’s t-test, chi square test, and Pearson’s correlation coefficient. A p-value of < 0.05 was considered statistically significant. Results: A total of 355 patients were hospitalized, and 30 of them were followed as outpatients. The mean CAR values of the hospitalized patients and the outpatients were 0.34 ± 0.89 and 0.39 ± 0.72 respectively (95% confidence interval [CI]: -0.31 to 0.40; p = 0.796). A 309 patients were hospitalized in wards and 46, in intensive care units; their mean CAR values were 0.33 ± 0.92 and 0.44 ± 0.74, respectively (95% CI: -0.17 to 0.39; p = 0.449). As the CAR value increased, the length of hospital stay also increased ( p < 0.0001). At the best cut-off point for COVID-19 diagnosis, CAR was shown to have 82.66% specificity, 69.72% sensitivity, 4.02 positive likelihood, and 0.37 negative likelihood. Conclusion: The length of hospital stay of the COVID-19 patients in the study was closely related to their CAR values obtained at the time of their first ED admission.