Venoms Can Be a Boon for Cancer Patients

Sudhir Kumar, Puja Sarkar, R. Jain
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引用次数: 2

Abstract

Cancer is one of the leading causes of death worldwide. Remarkable progress has recently been made toward understanding the proposed hallmarks of cancer development and treatment. Treatment modali- ties comprise radiation therapy, surgery, chemotherapy, immunotherapy, and hormonal therapy. The use of chemotherapeutics currently remains the predominant option for cancer therapy. One of the major problems with successful cancer therapy using chemotherapeutics is that patients often do not respond or eventually develop resistance after initial treatment. This issue has led to the increased use of anticancer drugs developed from natural resources. The biodiversity of venoms and toxins make them a unique source from which new therapeu- tics may be developed. Some molecules of venom are under clinical trials and may be utilized in anticancer drug development in the near future. This review discusses the anticancer potential of different venoms, surveys the pharmacology of venom peptides, and assesses their therapeutic prospects.
毒液可能是癌症患者的福音
癌症是世界范围内导致死亡的主要原因之一。最近在了解癌症发展和治疗的特征方面取得了显著进展。治疗方式包括放射治疗、手术、化疗、免疫治疗和激素治疗。使用化学疗法目前仍然是癌症治疗的主要选择。使用化疗药物成功治疗癌症的一个主要问题是,患者通常在初始治疗后没有反应或最终产生耐药性。这个问题导致了从自然资源中开发的抗癌药物的使用增加。毒液和毒素的生物多样性使它们成为开发新疗法的独特来源。一些毒液分子正在进行临床试验,可能在不久的将来用于抗癌药物的开发。本文综述了不同毒液的抗癌潜力,综述了毒液肽的药理作用,并对其治疗前景进行了展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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