Ultrasound-Assisted Emulsified Microextraction Based on Deep Eutectic Solvent for Trace Residue Analysis of Metribuzin in Urine Samples

IF 0.7 Q4 CHEMISTRY, ANALYTICAL

Methods and Objects of Chemical Analysis Pub Date : 2021-01-01 DOI:10.17721/moca.2021.153-161

M. Pourhossein, O. Heravizadeh, F. Omidi, M. Khadem, S. Shahtaheri

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引用次数: 9

Abstract

Deep eutectic solvent was used as extraction solvent to develop and optimize a new sample preparation method for the determination of metribuzin in urine samples. In order to determine the optimal values of the effective factors in the deep eutectic solvent-based ultrasound assisted emulsification microextraction method, six effective parameters were selected. The design of experiments was performed using the onevariable- at-a-time method. Totally, 96 experimental runs were performed, and the samples were analyzed using high-performance liquid chromatography with a UV detector. Under the optimum conditions, the calibration curve for metribuzin was linear in the concentration range of 5 to 500 μg L-1 for urine samples. The accuracy and reproducibility of the introduced method were determined using the relative recovery (RR %) and relative standard deviation (RSD %) tests on the fortified urine samples. RR % and RSD % were found to be 96.3 – 101.7 % and 3.2 – 7.6 %, respectively. The limit of quantification and the limit of detection were obtained 5 and 0.8 μg L-1, respectively.

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基于深度共熔溶剂的超声辅助乳化微萃取法分析尿中微量残留的美曲霉嗪

以深共晶溶剂为萃取溶剂，建立并优化了一种新的制样方法，用于测定尿样中美曲津的含量。为了确定深共晶溶剂基超声辅助乳化微萃取法中有效因素的最佳值，选取了6个有效参数。实验设计采用单变量一次法进行。共进行96次实验，采用高效液相色谱法和紫外检测器对样品进行分析。在最佳条件下，尿样品中美曲津在5 ~ 500 μg L-1的浓度范围内呈线性关系。采用强化尿液样品的相对回收率(RR %)和相对标准偏差(RSD %)检验方法的准确性和重复性。RR %为96.3 ~ 101.7%，RSD %为3.2 ~ 7.6%。定量限为5 μg L-1，检出限为0.8 μg L-1。

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来源期刊

Methods and Objects of Chemical Analysis CHEMISTRY, ANALYTICAL-

CiteScore

1.00

自引率

14.30%

发文量

期刊介绍： The journal "Methods and objects of chemical analysis" is peer-review journal and publishes original articles of theoretical and experimental analysis on topical issues and bio-analytical chemistry, chemical and pharmaceutical analysis, as well as chemical metrology. Submitted works shall cover the results of completed studies and shall make scientific contributions to the relevant area of expertise. The journal publishes review articles, research articles and articles related to latest developments of analytical instrumentations.