Assessment of the State of Platelet Haemostasis and Adhesive - Aggregation Properties of Platelets as a Factor of Increasing the Tendency to Thrombosis in Chronic Inflammation

IF 0.4 Q4 CHEMISTRY, ANALYTICAL
I. Sokolovskaya, N. Prybora, Valentyna Nechyporenko Valentyna Nechyporenko, O. Pozdniakova, Nataliia Hordiienko, Kostiantyn Nechyporenko, Yuliia Siliavina, V. Mavrin, Andriy Kotuza, O. Kliusov, I. Kryachok, I. Tytorenko, V.А. Zub, Lesya Yanitka, Nina Hordienko, M. Kudinova, Zhalie Mamedli, Lyudmila Hordiienko, Y. Kmetyuk, N. Sprynchuk
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Abstract

In recent decades, considerable progress has been made in understanding the functional mechanisms of platelets and the correction of platelet haemostasis. Platelets are considered the most important participants in both the normal and pathological thrombotic processes characteristic of a variety of diseases and conditions. Alterations in various limbs of haemostasis are found in many somatic diseases (atherosclerosis, coronary heart disease, stroke), surgical procedures, oncological and immunological diseases. Inflammation underlies most diseases and remains an urgent problem in medicine. In the leukocyte infiltration of the inflammatory focus, the mechanism of its self-preservation is of great importance. The activation of haematopoiesis during inflammation is triggered by factors released by stimulated leukocytes of the focus and peripheral blood. Therefore, the problem of the state of the haemostasis system should be the focus of constant attention of clinicians, and with the help of laboratory monitoring of the state of the haemostasis system, it is possible to carry out drug correction of the haemocoagulation potential.
慢性炎症患者血小板止血状态及血小板黏附聚集特性作为增加血栓形成倾向因素的评估
近几十年来,在了解血小板的功能机制和血小板止血的纠正方面取得了相当大的进展。血小板被认为是各种疾病和病症的正常和病理血栓形成过程中最重要的参与者。在许多躯体疾病(动脉粥样硬化、冠心病、中风)、外科手术、肿瘤和免疫疾病中都发现了各种肢体止血功能的改变。炎症是大多数疾病的基础,也是医学上的一个紧迫问题。在白细胞浸润炎性病灶中,其自我保存的机制具有重要意义。炎症期间造血的激活是由病灶和外周血中受刺激的白细胞释放的因子触发的。因此,止血系统状态的问题应该是临床医生不断关注的重点,借助实验室对止血系统状态的监测,才有可能对凝血电位进行药物校正。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
French-Ukrainian Journal of Chemistry
French-Ukrainian Journal of Chemistry CHEMISTRY, ANALYTICAL-
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0.00%
发文量
13
审稿时长
4 weeks
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