Development and Validation of a Simple Procedure for the Kinetic Spectrophotometric Quantitative Determination of Ceftriaxone Using Potassium Caroate

Abstract

A simple procedure for the quantitative determination of the Ceftriaxone pure substance by the spectrophotometric method in its kinetic modification using Caro’s acid has been developed and validated. The scheme of the chemical transformation of Ceftriaxone with the reaction of potassium caroate has been proposed. The appearance of a new wave gives the possibility of developing a new procedure for the quantitative determination of Ceftriaxone. The obtained results of accuracy and precision are as follows: RSD = 1.63-2.25 %, δ = 0.33-0.96 %. LOD = 0.1 µg/mL, LOQ = 0.33 µg/mL.