Commercial Development of Palladium(0) Catalysts for Highly Selective Cross-Coupling Reactions

Abstract

Johnson Matthey, Catalysis and Chiral Technologies, 2001 Nolte Drive, West Deptford, New Jersey 08066, USA Email: colactj@jmusa.com Palladium-catalysed cross-coupling has huge importance for the synthesis of many organic molecules at both laboratory and industrial scale. A range of commercially available preformed (R3P)2Pd(0) catalysts have now been developed and are available from Johnson Matthey. Some unique and highly selective applications of these palladium catalysts for various cross-coupling reactions, including novel reactions such as carbohalogenation reactions, Negishi coupling of aryl chlorides and copper-free Sonogashira coupling, are highlighted in this review.