Scaffold based on castor oil as an osteoconductive matrix in bone repair: biocompatibility analysis

IF 1 4区化学 Q4 POLYMER SCIENCE

Polimeros-ciencia E Tecnologia Pub Date : 2022-01-01 DOI:10.1590/0104-1428.210018

F. Lima, Luis Felipe Matos, Isnayra Kerolaynne Carneiro Pacheco, F. Reis, J. Câmara, J. Pierote, José Milton Matos, Alessandra A. Ribeiro, W. Moura, Ana Cristina Fialho

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引用次数: 2

Abstract

e Química Fina, Universidade Católica Portuguesa, Porto, Portugal *jvfrazao92@hotmail.com Obstract To analyze the biocompatibility of the scaffold produced from a natural polymer derived from castor oil through hemolytic activity and antimicrobial activity, to enable the clinical application. Three in vitro tests were performed: Hemolytic activity test - Polymer partially dissolved in contact with blood agar; Hemolytic activity test in sheep’s blood - Polymer extract with red blood cells solution; Antimicrobial activity test - Solid polymer in direct contact with E. Coli and S. Aureus. For hemolytic tests, none of the samples showed hemolysis. Negative hemolytic activity is a good indicator, as the maintenance of the blood clot in the area of the lesion is essential for the formation of new tissue. For the antimicrobial activity test, no significant activity was observed against the bacteria used. The polymer is not toxic to red blood cells, being

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以蓖麻油为骨传导基质的骨修复支架:生物相容性分析

e Química Fina, Universidade Católica portuesa, Porto, Portugal *jvfrazao92@hotmail.com摘要通过对蓖麻油衍生的天然聚合物制备的支架的溶血活性和抗菌活性进行生物相容性分析，为其临床应用奠定基础。进行了三项体外试验:溶血活性试验——与血琼脂接触部分溶解的聚合物;绵羊血液溶血活性试验。红细胞溶液聚合物提取物抗菌活性试验-与大肠杆菌和金黄色葡萄球菌直接接触的固体聚合物。对于溶血试验，没有样品显示溶血。阴性溶血活性是一个很好的指标，因为维持病变区域的血凝块对新组织的形成至关重要。对于抗菌活性试验，没有观察到对所用细菌的显著活性。这种聚合物对红细胞没有毒性，因为

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来源期刊

Polimeros-ciencia E Tecnologia 化学-高分子科学

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Polímeros is a quarterly publication of the Associação Brasileira de Polímeros - ABPol (Brazilian Polymer Association), which publishes Review Articles, Original Articles and Short Communications, disclosing advances in the knowledge of Polymer Science and Technology.