ГЕНЕТИЧЕСКИЕ ВАРИАНТЫ ВИРУСА ГЕПАТИТА B У ПЕРВИЧНЫХ ДОНОРОВ В Г. АСТАНА, КАЗАХСТАН

IF 0.2 Q4 INFECTIOUS DISEASES

Infektsiya i Immunitet Pub Date : 2016-01-01 DOI:10.15789/2220-7619-2016-4-359-365

Yu. V. Ostankova, A. V. Semenov, Z. K. Burkitbayev, T. N. Savchuk, A. A. Totolian

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引用次数: 3

Abstract

The prevalence of one of the hepatotropic virus, hepatitis B virus (HBV) remains a serious global health problem. Since hepatitis B is transmitted through contact with blood or other fluids of an infected person, blood safety is one of the major public health issues in regions with high virus prevalence. Observed in recent years the trend to a shift in the prevalence of various genotypes of HBV in different geographical areas due to immigration from regions of the world with a high incidence of hepatotropic viruses, makes doctors and epidemiologists to pay close attention to the epidemiological situation in neighboring countries. The aim of our work was to study the characteristics of the genetic structure of the HBV in primary donors in Astana, Kazakhstan. A total of 30 blood plasma samples from newly diagnosed hepatitis B (HBsAg+) of Astana. HBV DNA was detected in 27 samples out of 30. Based on the phylogenetic analysis of the isolates showed that among patients examined HBV identified mainly D genotype, which is the most common genotype of HBV in Central Asia. Thus HBV subtype predominant D1 (85,2%) compared to the HBV subtype D2 (3,7%) and subtype D3 (7,4%), in a single sample was detected HBV genotypes A subtype A1. High similarities identified isolates previously described in Iran, Sudan, Mongolia, Tunisia suggest numerous independent, perhaps mutual, the importation of the virus in the country, including in the major migration waves. First detected at the territory of Kazakhstan HBV subtype A1, uncharacteristic for the region, as well as subtypes D2 and D3, which have a high similarity with the nucleotide sequences of HBV in Russia, show cases of importation of the virus from other countries. Identification of the propagation and the role of «imported» genotypes of HBV virus in circulation may be essential for regions where the prevalence of hepatotropic viruses is high, and the genome structure and the way of their distribution sufficiently studied.

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乙型肝炎病毒在G的主要捐赠者中的遗传变异哈萨克斯坦阿斯塔纳

嗜肝病毒之一的乙型肝炎病毒(HBV)的流行仍然是一个严重的全球卫生问题。由于乙型肝炎是通过接触感染者的血液或其他液体传播的，因此血液安全是病毒高流行地区的主要公共卫生问题之一。近年来，由于来自世界上嗜肝病毒高发地区的移民，在不同地理区域内各种基因型HBV的流行趋势发生了变化，这使得医生和流行病学家密切关注周边国家的流行病学情况。我们工作的目的是研究哈萨克斯坦阿斯塔纳原发性献血者HBV遗传结构的特征。阿斯塔纳市新诊断的乙型肝炎(HBsAg+)共30份血浆样本。30份样本中有27份检测到HBV DNA。基于分离株的系统发育分析显示，在检查的患者中，HBV主要鉴定为D基因型，这是中亚地区最常见的HBV基因型。因此，在单个样本中检测到的HBV基因型为A1亚型，D1亚型(85.2%)高于D2亚型(3.7%)和D3亚型(7.4%)。先前在伊朗、苏丹、蒙古和突尼斯所发现的分离株高度相似，表明该国有许多独立的，也许是相互的病毒输入，包括在主要的迁徙浪潮中。首先在哈萨克斯坦境内检测到的乙型肝炎病毒A1亚型(该地区不具有特征性)，以及与俄罗斯乙型肝炎病毒核苷酸序列高度相似的D2和D3亚型，表明该病毒是从其他国家输入的。在嗜肝病毒流行率高的地区，鉴定HBV病毒“输入”基因型的传播和作用可能至关重要，并且对其基因组结构和分布方式进行充分研究。

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来源期刊

Infektsiya i Immunitet INFECTIOUS DISEASES-

CiteScore

1.40

自引率

50.00%

发文量

审稿时长

10 weeks

期刊介绍： Journal "Infektsiya i immunitet" ("Russian Journal of Infection and Immunity") established by Northwest Branch of RAMS, St. Petersburg Pasteur Institute and the St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists, with the participation of the St. Petersburg branch of All-Russian Practical Society of epidemiologists, microbiologists and parasitologists at St. Petersburg and Leningrad region. The journal is devoted to numerous aspects of the interaction between different microorganisms and the host organism. Journal is of interest for microbiologists, immunologists, epidemiologists and clinicians. The most detailed discussion of the following questions: • molecular basis of infections caused by pathogenic bacteria, fungi and parasites; • mechanisms of pathogenicity of microorganisms; • the impact of microbial virulence factors on host cells; • factors and mechanism to protect the host from infection; • factors of nonspecific and specific immunity; • experimental models of infectious disease; • development of vaccines and nonspecific anti-infectious defense.