КЛИНИКО-ИММУНОЛОГИЧЕСКАЯ ХАРАКТЕРИСТИКА БОЛЬНЫХ С ГЕРПЕСВИРУСНОЙ ИНФЕКЦИЕЙ РАЗЛИЧНОЙ ТЯЖЕСТИ

IF 0.2 Q4 INFECTIOUS DISEASES

Infektsiya i Immunitet Pub Date : 2015-02-03 DOI:10.15789/2220-7619-2014-4-359-364

T. M. Lyuboshenko, T. I. Dolgikh

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引用次数: 3

Abstract

The peculiarities of clinical signs, immune and interferon status in 180 patients with laboratory confirmed infection of varying severity, caused by herpes simplex virus (VSHI) have been studied. It was determined that frequency of bacterial infections is increased in patients with more severe clinical forms of VSHI. In patients with mild course furunculosis was more often detected than in other groups. In patients with moderate course of VSHI vaginal candidiasis was more common. In patients with severe VSHI course the combination of labial and genital herpes as well as infection caused by the human papilloma virus were more prevalent. In case of severe infection occurred an increased frequency of dysbiosis, fatigue, low grade temperature, iron deficiency anemia and malignancies. The highest frequency of allergic reactions is observed in patients with moderate course of VSHI. The autoimmune syndrome manifestations were not depend on the severity of VSHI. The degree of reduction of cell immunity and disorders in the system of interferon were closely related to severity of VSHI course.

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不同重度疱疹病毒感染者的临床免疫特征

本文对180例实验室确诊的不同程度单纯疱疹病毒(VSHI)感染患者的临床体征、免疫和干扰素水平的特点进行了研究。经确定，细菌性感染的频率在VSHI临床形式较严重的患者中增加。在病程较轻的患者中，疖病的检出率高于其他组。在中度VSHI患者中阴道念珠菌感染更为常见。在严重的VSHI病程中，阴唇疱疹和生殖器疱疹合并以及人乳头瘤病毒感染更为普遍。在严重感染的情况下，发生生态失调、疲劳、低热、缺铁性贫血和恶性肿瘤的频率增加。过敏反应发生率最高的是中度VSHI患者。自身免疫综合征的表现与VSHI的严重程度无关。细胞免疫功能降低程度和干扰素系统紊乱程度与VSHI病程的严重程度密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infektsiya i Immunitet INFECTIOUS DISEASES-

CiteScore

1.40

自引率

50.00%

发文量

审稿时长

10 weeks

期刊介绍： Journal "Infektsiya i immunitet" ("Russian Journal of Infection and Immunity") established by Northwest Branch of RAMS, St. Petersburg Pasteur Institute and the St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists, with the participation of the St. Petersburg branch of All-Russian Practical Society of epidemiologists, microbiologists and parasitologists at St. Petersburg and Leningrad region. The journal is devoted to numerous aspects of the interaction between different microorganisms and the host organism. Journal is of interest for microbiologists, immunologists, epidemiologists and clinicians. The most detailed discussion of the following questions: • molecular basis of infections caused by pathogenic bacteria, fungi and parasites; • mechanisms of pathogenicity of microorganisms; • the impact of microbial virulence factors on host cells; • factors and mechanism to protect the host from infection; • factors of nonspecific and specific immunity; • experimental models of infectious disease; • development of vaccines and nonspecific anti-infectious defense.