INFLUENCE OF CHITOSAN ON THE PROPERTIES OF GELS PROTECTING OF THE ESOPHAGEAL MUCOSA

IF 0.8 Q4 MATERIALS SCIENCE, BIOMATERIALS

Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2019-09-30 DOI:10.15259/pcacd.24.012

K. Małolepsza-Jarmołowska

引用次数: 1

Abstract

Gastro-esophageal reflux is a term that defines the reverse flow of acid gastric contents into the esophagus. On the other hand, alkaline reflux occurs in the case when alkaline intestinal contents enter the esophagus. The aim of the study was to examine the pharmaceutical properties of gels for the treatment of gastro-esophageal reflux, covering the mucosa, allowing prolonged contact with the esophageal mucosa. Formulations containing the PVP K-30 showed the lowest pH, which is an important feature and can be used in the treatment of advanced alkaline reflux. Gels containing PVP K-90 and chitosan can be used in the treatment of acid reflux. The addition of chitosan significantly increased the dynamic viscosity of the tested gels. The study of the work of adhesion showed the effect of PVP K-30 and PVP K-90 and their concentration on the value of the work of adhesion. The presented studies have shown that it is possible to obtain gels with high adhesion to the esophageal mucous membrane.

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壳聚糖对食管黏膜保护凝胶性能的影响

胃食管反流是指胃内容物反流进入食道。另一方面，当碱性肠内容物进入食道时，会发生碱性反流。该研究的目的是检查用于治疗胃食管反流的凝胶的药物特性，覆盖粘膜，允许与食管粘膜长时间接触。含有PVP K-30的配方显示出最低的pH值，这是一个重要的特征，可用于治疗晚期碱性回流。含有PVP K-90和壳聚糖的凝胶可用于治疗胃酸反流。壳聚糖的加入显著提高了凝胶的动态粘度。黏附功的研究表明PVP K-30和PVP K-90及其浓度对黏附功值的影响。所提出的研究表明，它是可能获得凝胶与食管粘膜高粘连。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress on Chemistry and Application of Chitin and its Derivatives MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

1.10

自引率

16.70%

发文量

期刊介绍： Progress in the Chemistry and Application of Chitin and its Derivatives is an annual journal focused on all aspects of production, modification, enzymology and application of chitin and its many derivatives, including chitosan. The journal publishes full-length papers as well as invited reviews. To be considered, papers must present original research that has not been published or accepted for publication elsewhere. The language of the journal will be English.