A Rare Comorbidity: Dermatitis Herpetiformis and Sarcoidosis - A Case Report

Serbian Journal of Dermatology and Venereology Pub Date : 2016-09-01 DOI:10.1515/sjdv-2016-0015

Stoyan Ivanov Pavlov, Irina Ivanova Ivanova, Hristo Boychev Popov, Maria Angelova Tzaneva, Peter Ivanov Ghenev

{"title":"A Rare Comorbidity: Dermatitis Herpetiformis and Sarcoidosis - A Case Report","authors":"Stoyan Ivanov Pavlov, Irina Ivanova Ivanova, Hristo Boychev Popov, Maria Angelova Tzaneva, Peter Ivanov Ghenev","doi":"10.1515/sjdv-2016-0015","DOIUrl":null,"url":null,"abstract":"Abstract Sarcoidosis is an enigmatic, multisystem granulomatous disease of unknown etiology and wide range of clinical presentations. Case report: A 54-year-old female presented with facial rash: polymorphic, round, infiltrated erythematous plaques, 1 - 3 cm in size, disseminated on several areas of the face. The medical history was consistent with dermatitis herpetiformis and persistent intrahepatic cholestasis. The laboratory test results suggested celiac disease (strong positivity of IgA anti-tissue transglutaminase antibodies) but upper endoscopy was not performed to confirm it. The skin biopsy revealed noncaseating epithelioid-cell granulomas, and negative direct immunofluorescence showed IgA deposits in the dermis. Sarcoidosis with cutaneous and hepatic involvement was established based on compatible clinical findings and supportive histology. The period between manifestations of Duhring disease and skin manifestations of sarcoidosis was 20 years. Conclusion: Our clinical case supports the hypothesis for common immune pathogenic factors in gluten-sensitive diseases and sarcoidosis. The simultaneous occurrence of celiac disease and sarcoidosis is rare, but should not be under recognized.","PeriodicalId":30659,"journal":{"name":"Serbian Journal of Dermatology and Venereology","volume":"8 1","pages":"171 - 176"},"PeriodicalIF":0.0000,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/sjdv-2016-0015","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Serbian Journal of Dermatology and Venereology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/sjdv-2016-0015","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Abstract Sarcoidosis is an enigmatic, multisystem granulomatous disease of unknown etiology and wide range of clinical presentations. Case report: A 54-year-old female presented with facial rash: polymorphic, round, infiltrated erythematous plaques, 1 - 3 cm in size, disseminated on several areas of the face. The medical history was consistent with dermatitis herpetiformis and persistent intrahepatic cholestasis. The laboratory test results suggested celiac disease (strong positivity of IgA anti-tissue transglutaminase antibodies) but upper endoscopy was not performed to confirm it. The skin biopsy revealed noncaseating epithelioid-cell granulomas, and negative direct immunofluorescence showed IgA deposits in the dermis. Sarcoidosis with cutaneous and hepatic involvement was established based on compatible clinical findings and supportive histology. The period between manifestations of Duhring disease and skin manifestations of sarcoidosis was 20 years. Conclusion: Our clinical case supports the hypothesis for common immune pathogenic factors in gluten-sensitive diseases and sarcoidosis. The simultaneous occurrence of celiac disease and sarcoidosis is rare, but should not be under recognized.

查看原文本刊更多论文

一罕见的合并症:疱疹样皮炎及结节病1例报告

结节病是一种病因不明、多系统肉芽肿性疾病，临床表现广泛。病例报告:一名54岁女性，面部皮疹:多形态，圆形，浸润性红斑斑块，大小1 - 3cm，散布于面部多个区域。病史符合疱疹样皮炎和持续性肝内胆汁淤积。实验室检查结果提示乳糜泻(IgA抗组织转谷氨酰胺酶抗体强阳性)，但未进行上内镜检查确认。皮肤活检显示非干酪化上皮样细胞肉芽肿，直接免疫荧光阴性显示真皮中IgA沉积。结节病累及皮肤和肝脏是建立在相容的临床表现和支持组织学。杜林病的表现与结节病的皮肤表现之间的时间间隔为20年。结论:本病例支持麸质敏感性疾病和结节病存在共同免疫致病因素的假说。乳糜泻和结节病同时发生是罕见的，但不应低估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Serbian Journal of Dermatology and Venereology

自引率

0.00%

发文量

期刊介绍： Serbian Journal of Dermatology and Venereology is a journal of the Serbian Association of Dermatologists and Venereologists. The journal is published in English, quarterly and intended to provide rapid publication of papers in the field of dermatology and venereology. Manuscripts are welcome from all countries in the following categories: editorials, original studies, review articles, professional articles, case reports, and history of medicine.